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    Bcl2l11 BCL2-like 11 (apoptosis facilitator) [ Mus musculus (house mouse) ]

    Gene ID: 12125, updated on 22-Apr-2017
    Official Symbol
    Bcl2l11provided by MGI
    Official Full Name
    BCL2-like 11 (apoptosis facilitator)provided by MGI
    Primary source
    MGI:MGI:1197519
    See related
    Ensembl:ENSMUSG00000027381 Vega:OTTMUSG00000015356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bim; Bod; bcl2-L-11; 1500006F24Rik
    Orthologs
    Location:
    2; 2 F1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (128126038..128162547)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (127951774..127988283)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene BUB1, mitotic checkpoint serine/threonine kinase Neighboring gene acyl-Coenzyme A oxidase-like Neighboring gene predicted gene, 19501 Neighboring gene predicted gene, 39926 Neighboring gene predicted gene 14009 Neighboring gene predicted gene 14005 Neighboring gene predicted gene 14010

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    B cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic process involved in embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process regulating host cell cycle in response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    developmental pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ear development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extrinsic apoptotic signaling pathway in absence of ligand IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    leukocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    leukocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lymphocyte homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid cell homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process by virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fibroblast apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    post-embryonic animal organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of developmental pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spleen development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thymocyte apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    tube formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    BIM-BCL-2 complex ISO
    Inferred from Sequence Orthology
    more info
     
    BIM-BCL-xl complex ISO
    Inferred from Sequence Orthology
    more info
     
    Bcl-2 family protein complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    bcl-2-like protein 11
    Names
    Bcl2 interacting mediator of cell death
    bcl2-interacting mediator of cell death

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284410.2NP_001271339.1  bcl-2-like protein 11 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' exon structure and it thus differs in both UTRs and in the 5' and 3' coding regions, and it also lacks an in-frame segment in the central coding region, compared to variant 1. The encoded isoform (4) has distinct N- and C-termini and is shorter than isoform 1.
      Source sequence(s)
      AK037885, AK162975, AL805950
      UniProtKB/TrEMBL
      Q3TR86
      Conserved Domains (1) summary
      pfam06773
      Location:78114
      Bim_N; Bim protein N-terminus
    2. NM_001291016.1NP_001277945.1  bcl-2-like protein 11 isoform 5

      See identical proteins and their annotated locations for NP_001277945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an in-frame segment in the central coding region, and lacks two 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK037885, AK162975
      Consensus CDS
      CCDS71141.1
      UniProtKB/TrEMBL
      Q3TR86, Q6PEB3
      Related
      ENSMUSP00000087062.5, OTTMUSP00000016363, ENSMUST00000089634.11, OTTMUST00000036400
      Conserved Domains (1) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
    3. NM_009754.3NP_033884.1  bcl-2-like protein 11 isoform 3

      See identical proteins and their annotated locations for NP_033884.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AA881651, AF032461, AK037885, AK082613, BE136124, CA321725, CB521709
      Consensus CDS
      CCDS16712.1
      UniProtKB/Swiss-Prot
      O54918
      UniProtKB/TrEMBL
      Q3U7X3, Q542N5
      Related
      ENSMUSP00000099500.1, OTTMUSP00000016365, ENSMUST00000103211.7, OTTMUST00000036403
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:4276
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. NM_207680.2NP_997563.1  bcl-2-like protein 11 isoform 1

      See identical proteins and their annotated locations for NP_997563.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA881651, AK037885, AK082613, BE136124, CA321725, CB521709
      Consensus CDS
      CCDS16713.1
      UniProtKB/Swiss-Prot
      O54918
      UniProtKB/TrEMBL
      Q542N5
      Related
      ENSMUSP00000105970.2, OTTMUSP00000016362, ENSMUST00000110341.8, OTTMUST00000036398
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:128162
      Bclx_interact; Bcl-x interacting, BH3 domain
    5. NM_207681.2NP_997564.1  bcl-2-like protein 11 isoform 2

      See identical proteins and their annotated locations for NP_997564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AA881651, AK037885, AK050192, AK082613, BE136124, CA321725, CB521709
      Consensus CDS
      CCDS16714.1
      UniProtKB/Swiss-Prot
      O54918
      UniProtKB/TrEMBL
      Q542N5
      Related
      ENSMUSP00000099499.1, OTTMUSP00000016364, ENSMUST00000103210.1, OTTMUST00000036402
      Conserved Domains (2) summary
      pfam06773
      Location:440
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:72106
      Bclx_interact; Bcl-x interacting, BH3 domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      128126038..128162547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498614.3XP_006498677.1  bcl-2-like protein 11 isoform X1

      Conserved Domains (2) summary
      pfam06773
      Location:78114
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:202236
      Bclx_interact; Bcl-x interacting, BH3 domain
    2. XM_006498616.3XP_006498679.1  bcl-2-like protein 11 isoform X3

      Conserved Domains (2) summary
      pfam06773
      Location:78114
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:146180
      Bclx_interact; Bcl-x interacting, BH3 domain
    3. XM_006498617.3XP_006498680.1  bcl-2-like protein 11 isoform X4

      Conserved Domains (2) summary
      pfam06773
      Location:78114
      Bim_N; Bim protein N-terminus
      pfam08945
      Location:116150
      Bclx_interact; Bcl-x interacting, BH3 domain
    4. XM_006498615.3XP_006498678.1  bcl-2-like protein 11 isoform X2

      Conserved Domains (1) summary
      pfam06773
      Location:78114
      Bim_N; Bim protein N-terminus
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