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    Kcnk7 potassium channel, subfamily K, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 16530, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kcnk7provided by MGI
    Official Full Name
    potassium channel, subfamily K, member 7provided by MGI
    Primary source
    MGI:MGI:1341841
    See related
    Ensembl:ENSMUSG00000024936 AllianceGenome:MGI:1341841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Knot; Mlk3; Kcnk6; Kcnk8; 2310014G03Rik
    Summary
    Predicted to enable potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport and stabilization of membrane potential. Predicted to act upstream of or within potassium ion transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; eye; genitourinary system; heart; and thymus. Orthologous to human KCNK7 (potassium two pore domain channel subfamily K member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in stomach adult (RPKM 3.0), testis adult (RPKM 2.9) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    19 A; 19 4.34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5754471..5757956)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5704471..5707984)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pecanex homolog 3 Neighboring gene microRNA 6987 Neighboring gene STARR-positive B cell enhancer ABC_E4259 Neighboring gene STARR-positive B cell enhancer ABC_E11012 Neighboring gene mitogen-activated protein kinase kinase kinase 11 Neighboring gene EH domain binding protein 1-like 1 Neighboring gene family with sequence similarity 89, member B Neighboring gene zinc ribbon domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Knockout of the gene encoding the K(2P) channel KCNK7 does not alter volatile anesthetic sensitivity. Yost CS, et al. Behav Brain Res, 2008 Nov 21. PMID 18572259, Free PMC Article
    2. Genomic organization and chromosomal localization of the murine 2 P domain potassium channel gene Kcnk8: conservation of gene structure in 2 P domain potassium channels. Bockenhauer D, et al. Gene, 2000 Dec 31. PMID 11167025
    3. Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure. Salinas M, et al. J Biol Chem, 1999 Apr 23. PMID 10206991
    4. Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19. Saridaki A, et al. Cytogenet Cell Genet, 2000. PMID 10894943
    5. Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1. Park YG, et al. Nat Genet, 2005 Oct. PMID 16142231, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables potassium ion leak channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in stabilization of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    potassium channel subfamily K member 7
    Names
    double-pore K(+) channel 3
    neuromuscular two p domain potassium channel
    putative potassium channel DP3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010609.4 → NP_034739.2  potassium channel subfamily K member 7 precursor

      See identical proteins and their annotated locations for NP_034739.2

      Status: VALIDATED

      Source sequence(s)
      AC134563
      Consensus CDS
      CCDS29477.1
      UniProtKB/TrEMBL
      Q3KNZ8, Q9JJ14
      Related
      ENSMUSP00000051278.4, ENSMUST00000052448.4
      Conserved Domains (1) summary
      pfam07885
      Location:89 → 140
      Ion_trans_2; Ion channel

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5754471..5757956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531666.5 → XP_006531729.1  potassium channel subfamily K member 7 isoform X1

      See identical proteins and their annotated locations for XP_006531729.1

      UniProtKB/TrEMBL
      A0A494B9E8
      Related
      ENSMUSP00000157581.2, ENSMUST00000236818.2
      Conserved Domains (1) summary
      pfam07885
      Location:88 → 115
      Ion_trans_2; Ion channel

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004138.1: Suppressed sequence

      Description
      NM_001004138.1: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2T1.3 GenPept UniProtKB/Swiss-Prot:Q9Z2T1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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