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    MSN2 stress-responsive transcriptional activator MSN2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855053, updated on 5-Nov-2017
    Gene symbol
    MSN2
    Gene description
    stress-responsive transcriptional activator MSN2
    Primary source
    SGD:S000004640
    Locus tag
    YMR037C
    Gene type
    protein coding
    RNA name
    stress-responsive transcriptional activator MSN2
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (344403..346517, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene endopeptidase catalytic subunit Neighboring gene putative tyrosine protein phosphatase MIH1 Neighboring gene copper chaperone CCS1 Neighboring gene chromatin-binding transcription coactivator SUB1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Autophagy - yeast, organism-specific biosystem (from KEGG)
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    • Autophagy - yeast, conserved biosystem (from KEGG)
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    • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
      Chromatin modifying enzymes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Chromatin organization, organism-specific biosystem (from REACTOME)
      Chromatin organization, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
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    • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
      Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
    • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
      MAPK Signaling Pathway, organism-specific biosystemThe MAPK/ERK pathway is a signal transduction pathway that couples intracellular responses to the binding of growth factors to cell surface receptors. In many cell types, activation of this pathway p...
    • MAPK signaling pathway - yeast, organism-specific biosystem (from KEGG)
      MAPK signaling pathway - yeast, organism-specific biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • MAPK signaling pathway - yeast, conserved biosystem (from KEGG)
      MAPK signaling pathway - yeast, conserved biosystemThe S. cerevisiae genome encodes multiple MAP kinase orthologs. One (Fus3) mediates cellular response to peptide pheromones. Another (Kss1) permits adjustment to nutrient limiting conditions. A third...
    • Meiosis - yeast, organism-specific biosystem (from KEGG)
      Meiosis - yeast, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, one pair of sister chromatids recombines with, th...
    • Meiosis - yeast, conserved biosystem (from KEGG)
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    • PKMTs methylate histone lysines, organism-specific biosystem (from REACTOME)
      PKMTs methylate histone lysines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    Products Interactant Other Gene Complex Source Pubs Description

    Gene Ontology Provided by GO

    Process Evidence Code Pubs
    age-dependent response to oxidative stress involved in chronological cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to blue light IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to methylmercury IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to methylmercury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to a hypotonic environment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to acidic pH IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to amino acid starvation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to cold IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to ethanol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to freezing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to heat stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to heat stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to hydrostatic pressure IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to increased salt IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to nitrosative stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter in response to zinc ion starvation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of replicative cell aging by regulation of transcription from RNA polymerase II promoter in response to caloric restriction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    replicative cell aging IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    stress-responsive transcriptional activator MSN2
    NP_013751.1
    • Stress-responsive transcriptional activator; activated in stochastic pulses of nuclear localization in response to various stress conditions; binds DNA at stress response elements of responsive genes; relative distribution to nucleus increases upon DNA replication stress

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      344403..346517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182534.1NP_013751.1  TPA: stress-responsive transcriptional activator MSN2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P33748
      Conserved Domains (4) summary
      COG5048
      Location:127594
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:649670
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:676698
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:661687
      zf-H2C2_2; Zinc-finger double domain
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