Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    GRIA1 glutamate ionotropic receptor AMPA type subunit 1 [ Homo sapiens (human) ]

    Gene ID: 2890, updated on 8-May-2017
    Official Symbol
    GRIA1provided by HGNC
    Official Full Name
    glutamate ionotropic receptor AMPA type subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:4571
    See related
    Ensembl:ENSG00000155511 MIM:138248; Vega:OTTHUMG00000130148
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUH1; GLUR1; GLURA; GluA1; HBGR1
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q33.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (153489615..153813873)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (152870084..153193429)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene transfer RNA-Cys (ACA) 1-1 Neighboring gene long intergenic non-protein coding RNA 1470 Neighboring gene RNA, 7SL, cytoplasmic 177, pseudogene Neighboring gene long intergenic non-protein coding RNA 1861 Neighboring gene uncharacterized LOC107986464

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide association study of aging.
    NHGRI GWA Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    NHGRI GWA Catalog
    Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
    NHGRI GWA Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    NHGRI GWA Catalog
    Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
    NHGRI GWA Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of glutamate receptor 1 is significantly upregulated in clade B Tat treated SK-N-MC neuroblastoma cells PubMed
    tat HIV-1 Tat-induced dendritic swellings that act in striatal neurons are regulated by NMDA and AMPA receptor-related events PubMed

    Go to the HIV-1, Human Interaction Database

    • Activation of AMPA receptors, organism-specific biosystem (from REACTOME)
      Activation of AMPA receptors, organism-specific biosystemAMPA receptors are functionally either Ca permeable or Ca impermeable based on the subunit composition. Ca permeability is determined by GluR2 subunit which undergoes post-transcriptional RNA editin...
    • Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystem (from REACTOME)
      Activation of NMDA receptor upon glutamate binding and postsynaptic events, organism-specific biosystemNMDA receptors are a subtype of ionotropic glutamate receptors that are specifically activated by a glutamate agonist N-methyl-D-aspartate (NMDA). Activation of NMDA receptor involves opening of the ...
    • Amphetamine addiction, organism-specific biosystem (from KEGG)
      Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amphetamine addiction, conserved biosystem (from KEGG)
      Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), organism-specific biosystem (from WikiPathways)
      Amyotrophic lateral sclerosis (ALS), organism-specific biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Amyotrophic lateral sclerosis (ALS), conserved biosystem (from KEGG)
      Amyotrophic lateral sclerosis (ALS), conserved biosystemAmyotrophic lateral sclerosis (ALS) is a progressive, lethal, degenerative disorder of motor neurons. The hallmark of this disease is the selective death of motor neurons in the brain and spinal cord...
    • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
      Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
    • Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystem (from WikiPathways)
      Association Between Physico-Chemical Features and Toxicity Associated Pathways, organism-specific biosystemThis pathway is based on Figure 8 of "Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome."(See bibliography). These 3 pathways demonstr...
    • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
      Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystem (from REACTOME)
      COPII (Coat Protein 2) Mediated Vesicle Transport, organism-specific biosystemCOPII components (known as Sec13p, Sec23p, Sec24p, Sec31p, and Sar1p in yeast) traffic cargo from the endoplasmic reticulum to the ER-Golgi intermediate compartment (ERGIC). COPII-coated vesicles wer...
    • Cargo concentration in the ER, organism-specific biosystem (from REACTOME)
      Cargo concentration in the ER, organism-specific biosystemComputational analysis suggests that ~25% of the proteome may be exported from the ER in human cells (Kanapin et al, 2003). These cargo need to be recognized and concentrated into COPII vesicles, wh...
    • Circadian entrainment, organism-specific biosystem (from KEGG)
      Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Circadian entrainment, conserved biosystem (from KEGG)
      Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
    • Common Pathways Underlying Drug Addiction, organism-specific biosystem (from WikiPathways)
      Common Pathways Underlying Drug Addiction, organism-specific biosystemThe pathway was modeled after Figure 2 in Li, et al. 2008 and is based on the common pathways identified in their study as well as protein interaction data. Specifically, glutamate and dopamine neuro...
    • Dopaminergic synapse, organism-specific biosystem (from KEGG)
      Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • Dopaminergic synapse, conserved biosystem (from KEGG)
      Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
    • EPHB forward signaling, organism-specific biosystem (from Pathway Interaction Database)
      EPHB forward signaling, organism-specific biosystem
      EPHB forward signaling
    • ER to Golgi Anterograde Transport, organism-specific biosystem (from REACTOME)
      ER to Golgi Anterograde Transport, organism-specific biosystemSecretory cargo destined to be secreted or to arrive at the plasma membrane (PM) leaves the ER via distinct exit sites. This cargo is destined for the Golgi apparatus for further processing.
    • Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystem (from REACTOME)
      Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity, organism-specific biosystemExcitatory synaptic transmission in the brain is carried out by glutamate receptors through the activation of both ionotropic and metabotropic receptors. Ionotropic glutamate receptors are of three ...
    • Glutamatergic synapse, organism-specific biosystem (from KEGG)
      Glutamatergic synapse, organism-specific biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Glutamatergic synapse, conserved biosystem (from KEGG)
      Glutamatergic synapse, conserved biosystemGlutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synap...
    • Long-term depression, organism-specific biosystem (from KEGG)
      Long-term depression, organism-specific biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term depression, conserved biosystem (from KEGG)
      Long-term depression, conserved biosystemCerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and...
    • Long-term potentiation, organism-specific biosystem (from KEGG)
      Long-term potentiation, organism-specific biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • Long-term potentiation, conserved biosystem (from KEGG)
      Long-term potentiation, conserved biosystemHippocampal long-term potentiation (LTP), a long-lasting increase in synaptic efficacy, is the molecular basis for learning and memory. Tetanic stimulation of afferents in the CA1 region of the hippo...
    • MECP2 and Associated Rett Syndrome, organism-specific biosystem (from WikiPathways)
      MECP2 and Associated Rett Syndrome, organism-specific biosystemMecp2 is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells. Mecp2 plays...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, organism-specific biosystem
      Neuroactive ligand-receptor interaction
    • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
      Neuroactive ligand-receptor interaction, conserved biosystem
      Neuroactive ligand-receptor interaction
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystem (from REACTOME)
      Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell, organism-specific biosystemThe neurotransmitter in the synaptic cleft released by the pre-synaptic neuron binds specific receptors located on the post-synaptic terminal. These receptors are either ion channels or G protein cou...
    • Nicotine addiction, organism-specific biosystem (from KEGG)
      Nicotine addiction, organism-specific biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Nicotine addiction, conserved biosystem (from KEGG)
      Nicotine addiction, conserved biosystemNicotine is one of the main psychoactive ingredients in tobacco that contributes to the harmful tobacco smoking habit. A common feature of addictive drugs, including nicotine, is that they increase d...
    • Post-translational protein modification, organism-specific biosystem (from REACTOME)
      Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
    • Protein-protein interactions at synapses, organism-specific biosystem (from REACTOME)
      Protein-protein interactions at synapses, organism-specific biosystemSynapses constitute highly specialized sites of asymmetric cell-cell adhesion and intercellular communication. Its formation involves the recruitment of presynaptic and postsynaptic molecules at newl...
    • Retrograde endocannabinoid signaling, organism-specific biosystem (from KEGG)
      Retrograde endocannabinoid signaling, organism-specific biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • Retrograde endocannabinoid signaling, conserved biosystem (from KEGG)
      Retrograde endocannabinoid signaling, conserved biosystemEndogenous cannabinoids (endocannabinoids) serve as retrograde messengers at synapses in various regions of the brain. The family of endocannabinoids includes at least five derivatives of arachidonic...
    • SALM protein interactions at the synapses, organism-specific biosystem (from REACTOME)
      SALM protein interactions at the synapses, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...
    • Trafficking of AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of AMPA receptors, organism-specific biosystemRepetitive presynaptic activity causes long lasting changes in the postsynaptic transmission by changing the type and the number of AMPA receptors. These changes are brought about by trafficking mec...
    • Trafficking of GluR2-containing AMPA receptors, organism-specific biosystem (from REACTOME)
      Trafficking of GluR2-containing AMPA receptors, organism-specific biosystemTrafficking of GluR2-containing receptors is governed by protein protein interactions that are regulated by phosphorylation events. GluR2 binds NSF and AP2 in the proximal C terminal region and binds...
    • Transmission across Chemical Synapses, organism-specific biosystem (from REACTOME)
      Transmission across Chemical Synapses, organism-specific biosystemChemical synapses are specialized junctions that are used for communication between neurons, neurons and muscle or gland cells. The synapse involves a pre-synaptic neuron and a post-synaptic neuron,...
    • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
      Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
    • Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystem (from REACTOME)
      Unblocking of NMDA receptor, glutamate binding and activation, organism-specific biosystemAt resting membrane potential the NMDA receptor is blocked by extracellular Mg2+ ions and therefore is not activated in this state by ligands (glutamate, glycine, NMDA). The voltage block is removed ...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    • cAMP signaling pathway, organism-specific biosystem (from KEGG)
      cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    • cAMP signaling pathway, conserved biosystem (from KEGG)
      cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC133252

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    COPII vesicle coating TAS
    Traceable Author Statement
    more info
     
    ER to Golgi vesicle-mediated transport TAS
    Traceable Author Statement
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
    PubMed 
    excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    long term synaptic depression IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    receptor internalization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of postsynaptic cytosolic calcium ion concentration IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    AMPA glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    AMPA glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    axonal spine IEA
    Inferred from Electronic Annotation
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendritic spine membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    endoplasmic reticulum-Golgi intermediate compartment membrane TAS
    Traceable Author Statement
    more info
     
    neuron spine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    postsynaptic density ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    glutamate receptor 1
    Names
    AMPA 1
    AMPA-selective glutamate receptor 1
    gluR-1
    gluR-A
    gluR-K1
    glutamate receptor, ionotropic, AMPA 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047078.1 RefSeqGene

      Range
      5829..329174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000827.3NP_000818.2  glutamate receptor 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000818.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB209094, AK310189, AL120214, DC335107, M81886, X58633
      Consensus CDS
      CCDS4322.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000285900.4, OTTHUMP00000160643, ENST00000285900.9, OTTHUMT00000252456
      Conserved Domains (4) summary
      cd06390
      Location:26389
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538817
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:37372
      ANF_receptor; Receptor family ligand binding region
    2. NM_001114183.1NP_001107655.1  glutamate receptor 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001107655.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a different coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is the same length but has a different internal segment, as compared to isoform 1.
      Source sequence(s)
      AB209094, AL120214, DC335107, M64752
      Consensus CDS
      CCDS47318.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000339343.5, OTTHUMP00000165781, ENST00000340592.9, OTTHUMT00000258854
      Conserved Domains (4) summary
      cd06390
      Location:26389
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:406787
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:538817
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:37372
      ANF_receptor; Receptor family ligand binding region
    3. NM_001258019.1NP_001244948.1  glutamate receptor 1 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001244948.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AB209094, AK295827, AL120214, DC335107
      Consensus CDS
      CCDS58986.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000427920.1, OTTHUMP00000224241, ENST00000518142.5, OTTHUMT00000374098
      Conserved Domains (4) summary
      cd13729
      Location:326707
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:458737
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:75292
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:26309
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    4. NM_001258020.1NP_001244949.1  glutamate receptor 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (4) is shorter at the N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AL120214, DC335107
      UniProtKB/TrEMBL
      Q59GL5
      Conserved Domains (4) summary
      cd13729
      Location:311692
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:443722
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1277
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1294
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    5. NM_001258021.1NP_001244950.1  glutamate receptor 1 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (5) has a longer and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295184, AK295827, AK315934, AL120214
      Consensus CDS
      CCDS58987.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000428994.1, OTTHUMP00000224242, ENST00000518783.1, OTTHUMT00000373902
      Conserved Domains (4) summary
      cd06390
      Location:36399
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:416797
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548827
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:47382
      ANF_receptor; Receptor family ligand binding region
    6. NM_001258022.1NP_001244951.1  glutamate receptor 1 isoform 6

      See identical proteins and their annotated locations for NP_001244951.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) has an alternate exon in place of the 5'-most exon of variant 1 and has an alternate in-frame exon in place of another exon of the same size. The resulting isoform (6) has a longer and distinct N-terminus and has a different sequence (but same length) segment in the C-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295184, AK315934, AL120214
      Consensus CDS
      CCDS58988.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000415569.2, OTTHUMP00000273550, ENST00000448073.8, OTTHUMT00000470859
      Conserved Domains (4) summary
      cd06390
      Location:36399
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:416797
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:548827
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:47382
      ANF_receptor; Receptor family ligand binding region
    7. NM_001258023.1NP_001244952.1  glutamate receptor 1 isoform 7

      See identical proteins and their annotated locations for NP_001244952.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has an alternate exon in place of the 5'-most exon of variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AB209094, AK295039, AL120214
      Consensus CDS
      CCDS58989.1
      UniProtKB/Swiss-Prot
      P42261
      UniProtKB/TrEMBL
      Q59GL5
      Related
      ENSP00000427864.2, OTTHUMP00000224243, ENST00000521843.6, OTTHUMT00000373905
      Conserved Domains (4) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:469748
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1303
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1320
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RNA

    1. NR_047578.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate 5' exon and an alternate 3' exon compared to variant 1. The resulting transcript is a candidate for nonsense-mediated mRNA decay (NMD) and is therefore thought to be non-protein coding.
      Source sequence(s)
      AB209094, AC091960, AK294011, AL120214, DC335107

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      153489615..153813873
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011537635.2XP_011535937.1  glutamate receptor 1 isoform X1

      Conserved Domains (4) summary
      cd06390
      Location:9369
      PBP1_iGluR_AMPA_GluR1; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR1 subunit of the AMPA receptor
      cd13729
      Location:386767
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:518797
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:17352
      ANF_receptor; Receptor family ligand binding region
    2. XM_017009393.1XP_016864882.1  glutamate receptor 1 isoform X3

      Conserved Domains (4) summary
      cd13729
      Location:337718
      PBP2_iGluR_AMPA_GluR1; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtype GluR1 of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:469748
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:1303
      ANF_receptor; Receptor family ligand binding region
      cl10011
      Location:1320
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily
    3. XM_017009392.1XP_016864881.1  glutamate receptor 1 isoform X2

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      152302506..152626274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center