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    Pygo2 pygopus 2 [ Mus musculus (house mouse) ]

    Gene ID: 68911, updated on 26-Nov-2016
    Official Symbol
    Pygo2provided by MGI
    Official Full Name
    pygopus 2provided by MGI
    Primary source
    MGI:MGI:1916161
    See related
    Ensembl:ENSMUSG00000047824 Vega:OTTMUSG00000022069
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190004M21Rik
    Orthologs
    Location:
    3; 3 F1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (89430117..89435131)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89234759..89239050)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1 Neighboring gene pre B cell leukemia transcription factor interacting protein 1 Neighboring gene phosphomevalonate kinase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to RNA polymerase II transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone acetyltransferase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    histone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chromatin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    post-embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    post-embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of histone H3-K4 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mammary gland epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatid development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    spermatid nucleus differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293763.1NP_001280692.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280692.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 5. Variants 2 through 5 encode the same isoform (b).
      Source sequence(s)
      AC171273, AI843615, AK132759, BY009144
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (1) summary
      cd15636
      Location:291344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    2. NM_001293766.1NP_001280695.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280695.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 5. Variants 2 through 5 encode the same isoform (b).
      Source sequence(s)
      AI843615, AK132759, BQ571639, BY249701
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (1) summary
      cd15636
      Location:291344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    3. NM_001293767.1NP_001280696.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_001280696.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents the shortest transcript and encodes the shorter isoform (b). Variants 2 through 5 encode the same isoform.
      Source sequence(s)
      AC171273, AI843615, AK132759
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (1) summary
      cd15636
      Location:291344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    4. NM_001293768.1NP_001280697.1  pygopus homolog 2 isoform a

      See identical proteins and their annotated locations for NP_001280697.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) contains an alternate 5' terminal exon resulting in the use of an alternate start codon compared to variant 5. The encoded isoform (a) has a longer N-terminus compared to isoform b.
      Source sequence(s)
      AC171273, AI843615, BY009144
      Consensus CDS
      CCDS79952.1
      UniProtKB/TrEMBL
      Q80V76
      Related
      ENSMUSP00000053672, OTTMUSP00000024844, ENSMUST00000060061, OTTMUST00000052396
      Conserved Domains (1) summary
      cd15636
      Location:328381
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
    5. NM_026869.3NP_081145.1  pygopus homolog 2 isoform b

      See identical proteins and their annotated locations for NP_081145.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 5. Variants 2 through 5 encode the same isoform (b).
      Source sequence(s)
      AI843615, AK132759
      Consensus CDS
      CCDS38494.1
      UniProtKB/TrEMBL
      Q3V113
      Related
      ENSMUSP00000103036, OTTMUSP00000024845, ENSMUST00000107413, OTTMUST00000052397
      Conserved Domains (1) summary
      cd15636
      Location:291344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      89430117..89435131
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502004.3XP_006502067.1  

      See identical proteins and their annotated locations for XP_006502067.1

      UniProtKB/TrEMBL
      Q3V113
      Conserved Domains (1) summary
      cd15636
      Location:291344
      PHD_PYGO2; PHD finger found in pygopus homolog 2 (PYGO2)
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