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    Hbegf heparin-binding EGF-like growth factor [ Mus musculus (house mouse) ]

    Gene ID: 15200, updated on 10-Sep-2017
    Official Symbol
    Hbegfprovided by MGI
    Official Full Name
    heparin-binding EGF-like growth factorprovided by MGI
    Primary source
    MGI:MGI:96070
    See related
    Ensembl:ENSMUSG00000024486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dtr; Dts; Hegfl; AW047313
    Orthologs
    Location:
    18 B2; 18 19.46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (36504927..36515805, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (36664581..36675459, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene cysteine-rich transmembrane module containing 1 Neighboring gene prefoldin 1 Neighboring gene predicted gene, 41698 Neighboring gene solute carrier family 4, sodium bicarbonate cotransporter, member 9

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC107656

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    epidermal growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    blastocyst growth TAS
    Traceable Author Statement
    more info
    PubMed 
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of elastin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of keratinocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of protein kinase B signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    wound healing, spreading of epidermal cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    proheparin-binding EGF-like growth factor
    Names
    diphtheria toxin receptor
    heparin binding epidermal growth factor-like growth factor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010415.2NP_034545.1  proheparin-binding EGF-like growth factor precursor

      See identical proteins and their annotated locations for NP_034545.1

      Status: VALIDATED

      Source sequence(s)
      AK145548, AK164309, AW489543
      Consensus CDS
      CCDS29153.1
      UniProtKB/Swiss-Prot
      Q06186
      UniProtKB/TrEMBL
      Q5FW64
      Related
      ENSMUSP00000025363.5, ENSMUST00000025363.5
      Conserved Domains (1) summary
      PHA02887
      Location:108148
      PHA02887; EGF-like protein; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      36504927..36515805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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