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    Hist1h4c histone cluster 1, H4c [ Mus musculus (house mouse) ]

    Gene ID: 319155, updated on 7-May-2017
    Official Symbol
    Hist1h4cprovided by MGI
    Official Full Name
    histone cluster 1, H4cprovided by MGI
    Primary source
    MGI:MGI:2448421
    See related
    Ensembl:ENSMUSG00000060678 Vega:OTTMUSG00000000559
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Sep 2015]
    Orthologs
    Location:
    13; 13 A3.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (23698084..23698458, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (23790007..23790318, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene histone cluster 1, H2bc Neighboring gene histone cluster 1, H1t Neighboring gene hemochromatosis Neighboring gene family with sequence similarity 113, member A pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    histone binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA replication-dependent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    DNA replication-independent nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of megakaryocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    nucleosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    histone H4
    Names
    germinal histone H4
    histone 1, H4c

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178208.2NP_835515.1  histone H4

      See identical proteins and their annotated locations for NP_835515.1

      Status: REVIEWED

      Source sequence(s)
      AL592149
      Consensus CDS
      CCDS26359.1
      UniProtKB/Swiss-Prot
      P62806
      UniProtKB/TrEMBL
      B2RTM0
      Related
      ENSMUSP00000100032.1, OTTMUSP00000000527, ENSMUST00000102967.1, OTTMUST00000001146
      Conserved Domains (2) summary
      PLN00035
      Location:1103
      PLN00035; histone H4; Provisional
      cd00076
      Location:18101
      H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      23698084..23698458 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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