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    Hdac3 histone deacetylase 3 [ Mus musculus (house mouse) ]

    Gene ID: 15183, updated on 21-Jan-2018
    Official Symbol
    Hdac3provided by MGI
    Official Full Name
    histone deacetylase 3provided by MGI
    Primary source
    MGI:MGI:1343091
    See related
    Ensembl:ENSMUSG00000024454 Vega:OTTMUSG00000017266
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AW537363
    Expression
    Ubiquitous expression in CNS E14 (RPKM 54.1), limb E14.5 (RPKM 54.1) and 28 other tissues See more
    Orthologs
    Location:
    18 19.81 cM; 18 B3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (37936971..37954988, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (38096625..38114642, complement)

    Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 37013 Neighboring gene predicted gene, 38666 Neighboring gene predicted gene, 38667 Neighboring gene protocadherin gamma subfamily A, 1 Neighboring gene protocadherin gamma subfamily A, 2 Neighboring gene protocadherin gamma subfamily A, 3 Neighboring gene protocadherin gamma subfamily B, 1 Neighboring gene protocadherin gamma subfamily A, 4 Neighboring gene protocadherin gamma subfamily B, 2 Neighboring gene protocadherin gamma subfamily A, 5 Neighboring gene protocadherin gamma subfamily A, 6 Neighboring gene protocadherin gamma subfamily A, 7 Neighboring gene protocadherin gamma subfamily B, 4 Neighboring gene protocadherin gamma subfamily A, 8 Neighboring gene protocadherin gamma subfamily B, 5 Neighboring gene protocadherin gamma subfamily A, 10 Neighboring gene protocadherin gamma subfamily A, 9 Neighboring gene protocadherin gamma subfamily A, 11 Neighboring gene protocadherin gamma subfamily B, 6 Neighboring gene protocadherin gamma subfamily B, 7 Neighboring gene protocadherin gamma subfamily A, 12 Neighboring gene protocadherin gamma subfamily B, 8 Neighboring gene protocadherin gamma subfamily C, 3 Neighboring gene protocadherin gamma subfamily C, 4 Neighboring gene protocadherin gamma subfamily C, 5 Neighboring gene predicted gene, 29994 Neighboring gene microRNA 6979 Neighboring gene diaphanous related formin 1 Neighboring gene FCH and double SH3 domains 1 Neighboring gene microRNA 6981 Neighboring gene RELT-like 2 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    NAD-dependent histone deacetylase activity (H3-K14 specific) IEA
    Inferred from Electronic Annotation
    more info
     
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    cyclin binding ISO
    Inferred from Sequence Orthology
    more info
     
    deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein deacetylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to fluid shear stress ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin organization TAS
    Traceable Author Statement
    more info
    PubMed 
    circadian regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone H4 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone H4-K12 deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone deacetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone deacetylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of JNK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of interleukin-1 production ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription factor import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    histone deacetylase complex TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional repressor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    histone deacetylase 3
    Names
    HD3
    HDAC3 splicing HDAC3alpha
    HDAC3 splicing HDAC3beta
    HDAC3 splicing HDAC3delta
    HDAC3 splicing HDAC3gamma
    NP_034541.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010411.2NP_034541.2  histone deacetylase 3

      See identical proteins and their annotated locations for NP_034541.2

      Status: VALIDATED

      Source sequence(s)
      AF098295, AK037478, BQ932476, CJ166955
      Consensus CDS
      CCDS37785.1
      UniProtKB/TrEMBL
      Q3UM33, Q9JM08
      Related
      ENSMUSP00000037981.7, OTTMUSP00000018789, ENSMUST00000043498.7, OTTMUST00000041787
      Conserved Domains (1) summary
      cd10005
      Location:3383
      HDAC3; Histone deacetylase 3 (HDAC3)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

      Range
      37936971..37954988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_385976.3 RNA Sequence

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