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    Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 [ Mus musculus (house mouse) ]

    Gene ID: 18212, updated on 8-Oct-2017
    Official Symbol
    Ntrk2provided by MGI
    Official Full Name
    neurotrophic tyrosine kinase, receptor, type 2provided by MGI
    Primary source
    MGI:MGI:97384
    See related
    Ensembl:ENSMUSG00000055254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
    Orthologs
    Location:
    13 B1; 13 31.2 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (58806569..59133970)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (58907957..59231337)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455J16 gene Neighboring gene ribosomal protein L13, pseudogene 2 Neighboring gene predicted gene, 40968 Neighboring gene predicted gene, 34245 Neighboring gene predicted gene, 34307 Neighboring gene predicted gene, 34354 Neighboring gene predicted gene, 34558

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Alcoholism, organism-specific biosystem (from KEGG)
      Alcoholism, organism-specific biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • Alcoholism, conserved biosystem (from KEGG)
      Alcoholism, conserved biosystemAlcoholism, also called dependence on alcohol (ethanol), is a chronic relapsing disorder that is progressive and has serious detrimental health outcomes. As one of the primary mediators of the reward...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • C030027L06Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    brain-derived neurotrophic factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    brain-derived neurotrophic factor-activated receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor-activated receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    neurotrophin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neurotrophin binding ISO
    Inferred from Sequence Orthology
    more info
     
    neurotrophin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    brain-derived neurotrophic factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brain-derived neurotrophic factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling using intracellular calcium source IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    feeding behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamate secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mechanoreceptor differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of anoikis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peripheral nervous system neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of axonogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of glucocorticoid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron projection development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of peptidyl-serine phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of dendrite development ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neurotransmitter secretion ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein kinase B signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal rod cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trans-synaptic signaling by neuropeptide, modulating synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    axon terminus ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    excitatory synapse ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perikaryon ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic active zone ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    rough endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    BDNF/NT-3 growth factors receptor
    Names
    neurotrophic tyrosine receptor kinase type 2
    trkB tyrosine kinase
    NP_001020245.1
    NP_001269890.1
    NP_032771.1
    XP_006517212.1
    XP_006517213.1
    XP_006517214.1
    XP_006517215.1
    XP_017170908.1
    XP_017170909.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025074.2NP_001020245.1  BDNF/NT-3 growth factors receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001020245.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      AC154755, AK147391, CJ098737
      Consensus CDS
      CCDS26573.1
      UniProtKB/Swiss-Prot
      P15209
      Related
      ENSMUSP00000078757.5, ENSMUST00000079828.6
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. NM_001282961.1NP_001269890.1  BDNF/NT-3 growth factors receptor isoform a precursor

      See identical proteins and their annotated locations for NP_001269890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a).
      Source sequence(s)
      AC154755, AK147391, AK160789
      Consensus CDS
      CCDS26573.1
      UniProtKB/Swiss-Prot
      P15209
      Related
      ENSMUSP00000153553.1, ENSMUST00000225488.1
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. NM_008745.3NP_032771.1  BDNF/NT-3 growth factors receptor isoform b precursor

      See identical proteins and their annotated locations for NP_032771.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK018789, AK147441, AK160789, BP757570
      Consensus CDS
      CCDS36685.1
      UniProtKB/Swiss-Prot
      P15209
      UniProtKB/TrEMBL
      Q3UHE3
      Related
      ENSMUSP00000153270.1, ENSMUST00000224259.1
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      58806569..59133970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517149.3XP_006517212.1  BDNF/NT-3 growth factors receptor isoform X1

      See identical proteins and their annotated locations for XP_006517212.1

      UniProtKB/Swiss-Prot
      P15209
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    2. XM_006517150.3XP_006517213.1  BDNF/NT-3 growth factors receptor isoform X2

      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    3. XM_006517151.3XP_006517214.1  BDNF/NT-3 growth factors receptor isoform X3

      Related
      ENSMUSP00000153333.1, ENSMUST00000224402.1
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam01462
      Location:3160
      LRRNT; Leucine rich repeat N-terminal domain
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    4. XM_006517152.3XP_006517215.1  BDNF/NT-3 growth factors receptor isoform X4

      See identical proteins and their annotated locations for XP_006517215.1

      UniProtKB/Swiss-Prot
      P15209
      UniProtKB/TrEMBL
      Q3UHE3
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    5. XM_017315419.1XP_017170908.1  BDNF/NT-3 growth factors receptor isoform X1

      UniProtKB/Swiss-Prot
      P15209
      Conserved Domains (7) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      cd05093
      Location:531818
      PTKc_TrkB; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B
      pfam07714
      Location:537806
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
    6. XM_017315420.1XP_017170909.1  BDNF/NT-3 growth factors receptor isoform X4

      UniProtKB/Swiss-Prot
      P15209
      UniProtKB/TrEMBL
      Q3UHE3
      Related
      ENSMUSP00000105464.2, ENSMUST00000109838.9
      Conserved Domains (6) summary
      cd05855
      Location:301379
      Ig_TrkB_d5; Fifth domain (immunoglobulin-like) of Trk receptor TrkB
      smart00410
      Location:204283
      IG_like; Immunoglobulin like
      sd00031
      Location:96116
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:92150
      LRR_8; Leucine rich repeat
      cl11960
      Location:204283
      Ig; Immunoglobulin domain
      cl15307
      Location:152195
      TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain
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