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    Calb1 calbindin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83839, updated on 26-Sep-2017
    Official Symbol
    Calb1provided by RGD
    Official Full Name
    calbindin 1provided by RGD
    Primary source
    RGD:69340
    See related
    Ensembl:ENSRNOG00000007456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CaBP28K
    Summary
    binds calcium; activity is vitamin D dependent [RGD, Feb 2006]
    Orthologs
    Location:
    5q13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (29538380..29562774)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 5 NC_005104.3 (34217930..34242324)

    Chromosome 5 - NC_005104.4Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 pseudogene Neighboring gene N-terminal EF-hand calcium binding protein 1 Neighboring gene uncharacterized LOC108350938 Neighboring gene transmembrane protein 64 Neighboring gene mitochondrial ribosomal protein L30 Neighboring gene 2,4-dienoyl-CoA reductase 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC93326

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration IC
    Inferred by Curator
    more info
    PubMed 
    vitamin D binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to organic substance IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to organic substance ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    learning or memory IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    long-term memory ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric collecting duct development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric collecting duct development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric connecting tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric connecting tubule development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric distal convoluted tubule development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric distal convoluted tubule development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metanephric part of ureteric bud development IEA
    Inferred from Electronic Annotation
    more info
     
    metanephric part of ureteric bud development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of long-term synaptic potentiation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of presynaptic cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    retina layer formation IEA
    Inferred from Electronic Annotation
    more info
     
    retina layer formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    short-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    short-term memory ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vitamin D metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    intracellular ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    terminal bouton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    calbindin
    Names
    D-28K
    calbindin 1, 28 kD
    calbindin D28
    cerebellar Ca-binding protein, spot 35 protein
    spot 35 protein
    vitamin D-dependent calcium-binding protein, avian-type

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031984.2NP_114190.1  calbindin

      See identical proteins and their annotated locations for NP_114190.1

      Status: VALIDATED

      Source sequence(s)
      BC081764, CK479935
      UniProtKB/Swiss-Prot
      P07171
      Related
      ENSRNOP00000010845.3, ENSRNOT00000010845.4
      Conserved Domains (3) summary
      cd00051
      Location:102171
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:104171
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:1582
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005104.4 Reference Rnor_6.0 Primary Assembly

      Range
      29538380..29562774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000073.1 Alternate Rn_Celera

      Range
      28581243..28605619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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