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    TRIM22 tripartite motif containing 22 [ Homo sapiens (human) ]

    Gene ID: 10346, updated on 12-Mar-2017
    Official Symbol
    TRIM22provided by HGNC
    Official Full Name
    tripartite motif containing 22provided by HGNC
    Primary source
    HGNC:HGNC:16379
    See related
    Ensembl:ENSG00000132274 MIM:606559; Vega:OTTHUMG00000066904
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RNF94; STAF50; GPSTAF50
    Summary
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
    Orthologs
    Location:
    11p15.4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (5689587..5710863)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (5710817..5732093)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TRIM6-TRIM34 readthrough Neighboring gene tripartite motif containing 5 Neighboring gene tripartite motif containing 34 Neighboring gene uncharacterized LOC107984302 Neighboring gene olfactory receptor family 52 subfamily U member 1 pseudogene Neighboring gene olfactory receptor family 52 subfamily N member 4 (gene/pseudogene) Neighboring gene olfactory receptor family 52 subfamily P member 1 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of tripartite motif containing 22 (TRIM22) in human B cells PubMed
    env HIV-1 gp120-treated vaginal epithelial cells show upregulation of tripartite motif containing 22 (TRIM22) expression as compared to untreated control PubMed
    Pr55(Gag) gag TRIM22 changes the sub-cellular localization of Gag protein. The catalytic cysteine residues C15 and C18 are important for the antiviral effects of TRIM22 PubMed
    gag IFN-beta-induced expression of TRIM22 restricts HIV-1 replication. TRIM22 inhibits the budding of HIV-1 Gag-only particles PubMed
    gag A direct or indirect interaction of TRIM21 with HIV-1 Gag induces encapsidation of TRIM21 into virus particles, leading to slightly reduced virus titers PubMed
    Tat tat HIV-1 and the viral protein Tat modulate the expression of tripartite motif-containing 22 (TRIM22; STAF50) in immature dendritic cells and monocyte-derived macrophages PubMed
    tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Staf50, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed
    tat Staf-50 downregulates transcription directed by the HIV-1 LTR promoter, suggesting an inhibition of HIV-1 Tat function PubMed
    tat Overexpression of Staf50, which is known to repress the activity of HIV-1 Tat, inhibits HIV-1 infection between 50% and 90% in 293 T CD4/CCR5 cells as well as in monocyte-derived macrophages (MAC) PubMed

    Go to the HIV-1, Human Interaction Database

    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Interferon gamma signaling, organism-specific biosystem (from REACTOME)
      Interferon gamma signaling, organism-specific biosystemInterferon-gamma (IFN-gamma) belongs to the type II interferon family and is secreted by activated immune cells-primarily T and NK cells, but also B-cells and APC. INFG exerts its effect on cells by ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: OR56B1

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding, bridging IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription corepressor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    Cajal body IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
     
    nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase TRIM22
    Names
    50 kDa-stimulated trans-acting factor
    RING finger protein 94
    RING-type E3 ubiquitin transferase TRIM22
    staf-50
    stimulated trans-acting factor (50 kDa)
    tripartite binding motif 22
    tripartite motif protein TRIM22
    tripartite motif-containing protein 22
    NP_001186502.1
    NP_006065.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199573.1NP_001186502.1  E3 ubiquitin-protein ligase TRIM22 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK298934, AL360190, BC022281, BC035582, DC364428, X82200
      UniProtKB/Swiss-Prot
      Q8IYM9
      UniProtKB/TrEMBL
      B4DQS5
      Conserved Domains (4) summary
      smart00336
      Location:92133
      BBOX; B-Box-type zinc finger
      pfam14942
      Location:133203
      Muted; Organelle biogenesis, Muted-like protein
      cd15824
      Location:295492
      SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
      cl17238
      Location:1559
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. NM_006074.4NP_006065.2  E3 ubiquitin-protein ligase TRIM22 isoform 1

      See identical proteins and their annotated locations for NP_006065.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK298934, AL360190, BC022281, BC035582, DC364428
      Consensus CDS
      CCDS41612.1
      UniProtKB/Swiss-Prot
      Q8IYM9
      UniProtKB/TrEMBL
      B4DQS5
      Related
      ENSP00000369299, OTTHUMP00000069823, ENST00000379965, OTTHUMT00000143387
      Conserved Domains (4) summary
      smart00336
      Location:92133
      BBOX; B-Box-type zinc finger
      pfam15035
      Location:129205
      Rootletin; Ciliary rootlet component, centrosome cohesion
      cd15824
      Location:299496
      SPRY_PRY_TRIM22; PRY/SPRY domain in tripartite motif-containing protein 22 (TRIM22), also known as RING finger protein 94 (RNF94) or Stimulated trans-acting factor of 50 kDa (STAF50)
      cl17238
      Location:1559
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

      Range
      5689587..5710863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018922.2 Alternate CHM1_1.1

      Range
      5709735..5731034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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