Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Col24a1 collagen, type XXIV, alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 71355, updated on 22-Apr-2017
    Official Symbol
    Col24a1provided by MGI
    Official Full Name
    collagen, type XXIV, alpha 1provided by MGI
    Primary source
    MGI:MGI:1918605
    See related
    Ensembl:ENSMUSG00000028197 Vega:OTTMUSG00000021259
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430404K19Rik
    Summary
    This gene encodes the alpha-1 subunit of type XXIV collagen, one of the low abundance fibril-forming collagens found in cartilage. The encoded protein has structural features of invertebrate fibrillar collagens and is expressed predominantly in bone tissue. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Orthologs
    Location:
    3; 3 H2
    Exon count:
    60
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (145292105..145552013)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (144955436..145214969)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 40163 Neighboring gene outer dense fiber of sperm tails 2-like Neighboring gene predicted gene, 35133 Neighboring gene zinc finger, HIT type 6 Neighboring gene predicted gene, 40164

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Markers

    Homology

    Clone Names

    • MGC107332

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    extracellular matrix structural constituent IEA
    Inferred from Electronic Annotation
    more info
     
    molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    hematopoietic progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cellular_component ND
    No biological Data available
    more info
     
    collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    collagen alpha-1(XXIV) chain
    Names
    procollagen, type XXIV, alpha 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317733.1NP_001304662.1  collagen alpha-1(XXIV) chain isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC123711, AC136729, AC161237
      Conserved Domains (2) summary
      pfam01391
      Location:411468
      Collagen; Collagen triple helix repeat (20 copies)
      cl02436
      Location:702884
      COLFI; Fibrillar collagen C-terminal domain
    2. NM_027770.3NP_082046.2  collagen alpha-1(XXIV) chain isoform 1 precursor

      See identical proteins and their annotated locations for NP_082046.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC123711, AC136729, AC161237
      Consensus CDS
      CCDS17892.1
      UniProtKB/Swiss-Prot
      Q30D77
      Related
      ENSMUSP00000029848.4, OTTMUSP00000023504, ENSMUST00000029848.4, OTTMUST00000050372
      Conserved Domains (3) summary
      pfam01391
      Location:12591316
      Collagen; Collagen triple helix repeat (20 copies)
      cl02436
      Location:15501732
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:41230
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      145292105..145552013
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319724.1XP_017175213.1  collagen alpha-1(XXIV) chain isoform X2

    2. XM_006502098.3XP_006502161.1  collagen alpha-1(XXIV) chain isoform X1

      See identical proteins and their annotated locations for XP_006502161.1

      UniProtKB/Swiss-Prot
      Q30D77
      Conserved Domains (3) summary
      pfam01391
      Location:12591316
      Collagen; Collagen triple helix repeat (20 copies)
      cl02436
      Location:15501732
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:41230
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    3. XM_006502097.3XP_006502160.1  collagen alpha-1(XXIV) chain isoform X1

      See identical proteins and their annotated locations for XP_006502160.1

      UniProtKB/Swiss-Prot
      Q30D77
      Conserved Domains (3) summary
      pfam01391
      Location:12591316
      Collagen; Collagen triple helix repeat (20 copies)
      cl02436
      Location:15501732
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:41230
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    4. XM_011240232.2XP_011238534.1  collagen alpha-1(XXIV) chain isoform X1

      See identical proteins and their annotated locations for XP_011238534.1

      UniProtKB/Swiss-Prot
      Q30D77
      Conserved Domains (3) summary
      pfam01391
      Location:12591316
      Collagen; Collagen triple helix repeat (20 copies)
      cl02436
      Location:15501732
      COLFI; Fibrillar collagen C-terminal domain
      cl22861
      Location:41230
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

    RNA

    1. XR_001783751.1 RNA Sequence

    2. XR_001783752.1 RNA Sequence

    Support Center