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    Nr5a1 nuclear receptor subfamily 5, group A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 26423, updated on 3-Sep-2017
    Official Symbol
    Nr5a1provided by MGI
    Official Full Name
    nuclear receptor subfamily 5, group A, member 1provided by MGI
    Primary source
    MGI:MGI:1346833
    See related
    Ensembl:ENSMUSG00000026751 Vega:OTTMUSG00000012867
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ELP; SF1; SF-1; Ad4BP; ELP-3; Ftzf1; STF-1; Ftz-F1
    Orthologs
    Location:
    2 B; 2 24.42 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (38692656..38714559, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (38548180..38570062, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene adhesion G protein-coupled receptor D2, pseudogene Neighboring gene predicted gene, 36744 Neighboring gene nuclear receptor subfamily 6, group A, member 1 Neighboring gene ribosomal protein L15, pseudogene 4 Neighboring gene nuclear receptor subfamily 6, group A, member 1, opposite strand Neighboring gene microRNA 181a-2

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC124277, MGC124278

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II distal enhancer sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    adrenal gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    adrenal gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    calcineurin-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    female gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    hormone metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hormone-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    luteinization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    maintenance of protein location in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    male gonad development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of female gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sex determination ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    steroidogenic factor 1
    Names
    adrenal 4-binding protein
    embryonal LTR-binding protein
    embryonal long terminal repeat-binding protein
    fushi tarazu 1 factor homolog
    fushi tarazu factor homolog 1
    steroid hormone receptor Ad4BP
    steroid hydroxylase positive regulator

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316687.1NP_001303616.1  steroidogenic factor 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134378, AL844842, CD348290
      Consensus CDS
      CCDS16011.1
      UniProtKB/Swiss-Prot
      P33242
      Related
      ENSMUSP00000108504.1, OTTMUSP00000013824, ENSMUST00000112883.7, OTTMUST00000030854
      Conserved Domains (3) summary
      cd07070
      Location:237460
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13105
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
      pfam15822
      Location:147217
      MISS; MAPK-interacting and spindle-stabilizing protein-like
    2. NM_139051.3NP_620639.1  steroidogenic factor 1

      See identical proteins and their annotated locations for NP_620639.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK134378
      Consensus CDS
      CCDS16011.1
      UniProtKB/Swiss-Prot
      P33242
      Related
      ENSMUSP00000028084.4, OTTMUSP00000013825, ENSMUST00000028084.4, OTTMUST00000030856
      Conserved Domains (3) summary
      cd07070
      Location:237460
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13105
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
      pfam15822
      Location:147217
      MISS; MAPK-interacting and spindle-stabilizing protein-like

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      38692656..38714559 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498056.3XP_006498119.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006498119.1

      Conserved Domains (2) summary
      cd07070
      Location:273496
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13141
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    2. XM_006498060.3XP_006498123.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006498123.1

      Conserved Domains (2) summary
      cd07070
      Location:273496
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13141
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    3. XM_006498058.3XP_006498121.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006498121.1

      Conserved Domains (2) summary
      cd07070
      Location:273496
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13141
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    4. XM_006498059.3XP_006498122.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006498122.1

      Conserved Domains (2) summary
      cd07070
      Location:273496
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13141
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    5. XM_006498057.3XP_006498120.1  steroidogenic factor 1 isoform X1

      See identical proteins and their annotated locations for XP_006498120.1

      Conserved Domains (2) summary
      cd07070
      Location:273496
      NR_LBD_SF-1; The ligand binding domain of nuclear receptor steroidogenic factor 1, a member of nuclear receptor superfamily
      cd07167
      Location:13141
      NR_DBD_Lrh-1_like; The DNA-binding domain of Lrh-1 like nuclear receptor family like is composed of two C4-type zinc fingers
    6. XM_017318656.1XP_017174145.1  steroidogenic factor 1 isoform X2

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