Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    CYP2E1 cytochrome P450 family 2 subfamily E member 1 [ Homo sapiens (human) ]

    Gene ID: 1571, updated on 8-Oct-2017
    Official Symbol
    CYP2E1provided by HGNC
    Official Full Name
    cytochrome P450 family 2 subfamily E member 1provided by HGNC
    Primary source
    HGNC:HGNC:2631
    See related
    Ensembl:ENSG00000130649 MIM:124040; Vega:OTTHUMG00000019322
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPE1; CYP2E; P450-J; P450C2E
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q26.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (133527363..133539116)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135340300..135352627)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378575 Neighboring gene uncharacterized LOC107984284 Neighboring gene synaptonemal complex central element protein 1 Neighboring gene shadow of prion protein pseudogene 1 Neighboring gene olfactory receptor family 6 subfamily L member 1 pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Knockdown of NOX2 and NOX4 by siRNA abrogates HIV-1 gp120-induced reactive oxygen species (ROS), suggesting that NOX2 and NOX4 are involved in ROS production through CYP2E1 in astrocytes PubMed
    env HIV-1 gp120 upregulates the expression of cytochrome p450 family proteins CYP2E1, CYP2D6, and CYP2B6 in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Potential readthrough

    Included gene: SYCE1

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    benzene metabolic process TAS
    Traceable Author Statement
    more info
     
    carbon tetrachloride metabolic process TAS
    Traceable Author Statement
    more info
     
    drug metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    drug metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    drug metabolic process TAS
    Traceable Author Statement
    more info
     
    epoxygenase P450 pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    halogenated hydrocarbon metabolic process TAS
    Traceable Author Statement
    more info
     
    heterocycle metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    monoterpenoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oxidation-reduction process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to organonitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    response to ozone IEA
    Inferred from Electronic Annotation
    more info
     
    steroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    triglyceride metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    intrinsic component of endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    cytochrome P450 2E1
    Names
    4-nitrophenol 2-hydroxylase
    CYPIIE1
    cytochrome P450, family 2, subfamily E, polypeptide 1
    cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
    cytochrome P450-J
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    xenobiotic monooxygenase
    NP_000764.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008383.1 RefSeqGene

      Range
      5001..16754
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000773.3NP_000764.1  cytochrome P450 2E1 precursor

      See identical proteins and their annotated locations for NP_000764.1

      Status: REVIEWED

      Source sequence(s)
      AL161645, BX951478, J02625
      Consensus CDS
      CCDS7686.1
      UniProtKB/Swiss-Prot
      P05181
      Related
      ENSP00000252945.3, ENST00000252945.7
      Conserved Domains (1) summary
      pfam00067
      Location:33489
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      133527363..133539116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      135620490..135632188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center