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    CD1A CD1a molecule [ Homo sapiens (human) ]

    Gene ID: 909, updated on 26-Nov-2016
    Official Symbol
    CD1Aprovided by HGNC
    Official Full Name
    CD1a moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:1634
    See related
    Ensembl:ENSG00000158477 HPRD:01776; MIM:188370; Vega:OTTHUMG00000017512
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R4; T6; CD1; FCB6; HTA1
    Summary
    This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
    Orthologs
    Location:
    1q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (158248329..158258269)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (158218119..158228059)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II 2 pseudogene 1 Neighboring gene CD1d molecule Neighboring gene ribosomal protein S10 pseudogene 8 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 5 Neighboring gene CD1b molecule Neighboring gene CD1c molecule

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) T cell differentiation precursor stage that initiates a D-J rearrangement of the TCRbeta locus PubMed
    nef CD1a molecules are downregulated by and co-localized with Nef in CD1a-transfected cells; this co-localization is dependent upon the CD1a cytoplasmic tail from amino acid position 325 to 327 PubMed
    Tat tat CD4 and CD1a surface expression are greatly decreased in Tat expression Jurkat cells PubMed
    tat Only the wild-type Tat induces CD1A-expressing MDDC maturation and increases the production of cytokines TNF-alpha, IL-12, MIP-1alpha, and MIP-1beta PubMed
    tat CD1A-expressing monocyte-derived dendritic cells (MDDC) efficiently uptake wild-type and Cys-22 Tat but not oxidized Tat PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of CD1A in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    beta-2-microglobulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    endogenous lipid antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    exogenous lipid antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lipopeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    antigen processing and presentation, exogenous lipid antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of immune response TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    T-cell surface glycoprotein CD1a
    Names
    CD1A antigen, a polypeptide
    T-cell surface antigen T6/Leu-6
    cluster of differentiation 1 A
    cortical thymocyte antigen CD1A
    differentiation antigen CD1-alpha-3
    epidermal dendritic cell marker CD1a
    hTa1 thymocyte antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001320652.1NP_001307581.1  T-cell surface glycoprotein CD1a isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK312945, AW949640, CA432941, DA822513
      UniProtKB/Swiss-Prot
      P06126
      Conserved Domains (2) summary
      cd07698
      Location:191284
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:12185
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    2. NM_001763.2NP_001754.2  T-cell surface glycoprotein CD1a isoform 1 precursor

      See identical proteins and their annotated locations for NP_001754.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL121986, CA432941, DB108750, M28825
      Consensus CDS
      CCDS1174.1
      UniProtKB/Swiss-Prot
      P06126
      Related
      ENSP00000289429, OTTHUMP00000018907, ENST00000289429, OTTHUMT00000046349
      Conserved Domains (2) summary
      cd07698
      Location:202295
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:19196
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      158248329..158258269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      159614493..159624433
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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