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    NOV nephroblastoma overexpressed [ Homo sapiens (human) ]

    Gene ID: 4856, updated on 12-Mar-2017
    Official Symbol
    NOVprovided by HGNC
    Official Full Name
    nephroblastoma overexpressedprovided by HGNC
    Primary source
    HGNC:HGNC:7885
    See related
    Ensembl:ENSG00000136999 MIM:164958; Vega:OTTHUMG00000164984
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCN3; NOVh; IBP-9; IGFBP9; IGFBP-9
    Summary
    The protein encoded by this gene is a small secreted cysteine-rich protein and a member of the CCN family of regulatory proteins. CNN family proteins associate with the extracellular matrix and play an important role in cardiovascular and skeletal development, fibrosis and cancer development. [provided by RefSeq, Feb 2009]
    Orthologs
    Location:
    8q24.12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 8 NC_000008.11 (119416312..119424438)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (120428552..120436678)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375726 Neighboring gene mal, T-cell differentiation protein 2 (gene/pseudogene) Neighboring gene microRNA 548az Neighboring gene zinc finger protein 532 pseudogene Neighboring gene ectonucleotide pyrophosphatase/phosphodiesterase 2 Neighboring gene cytochrome c, somatic pseudogene 23

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    NHGRI GWA Catalog
    Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Notch binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    integrin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    bone regeneration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell adhesion mediated by integrin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelial cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endothelial cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fibroblast migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    hematopoietic stem cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of NF-kappaB import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of SMAD protein import into nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of chondrocyte proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of insulin secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of monocyte chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of myotube differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    type B pancreatic cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    gap junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gap junction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein NOV homolog
    Names
    CCN family member 3
    IGF-binding protein 9
    insulin-like growth factor-binding protein 9
    nephroblastoma-overexpressed gene protein homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009779.1 RefSeqGene

      Range
      5001..13127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002514.3NP_002505.1  protein NOV homolog precursor

      See identical proteins and their annotated locations for NP_002505.1

      Status: REVIEWED

      Source sequence(s)
      AC021733, AY082381, DA162276
      Consensus CDS
      CCDS6328.1
      UniProtKB/Swiss-Prot
      P48745
      UniProtKB/TrEMBL
      A0A024R9J4
      Related
      ENSP00000259526, OTTHUMP00000228107, ENST00000259526, OTTHUMT00000381301
      Conserved Domains (3) summary
      smart00121
      Location:3395
      IB; Insulin growth factor-binding protein homologues
      smart00041
      Location:269338
      CT; C-terminal cystine knot-like domain (CTCK)
      smart00214
      Location:110170
      VWC; von Willebrand factor (vWF) type C domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p7 Primary Assembly

      Range
      119416312..119424438
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018919.2 Alternate CHM1_1.1

      Range
      120469559..120477685
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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