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    Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) [ Mus musculus (house mouse) ]

    Gene ID: 14811, updated on 15-Aug-2017
    Official Symbol
    Grin2aprovided by MGI
    Official Full Name
    glutamate receptor, ionotropic, NMDA2A (epsilon 1)provided by MGI
    Primary source
    MGI:MGI:95820
    See related
    Ensembl:ENSMUSG00000059003 Vega:OTTMUSG00000016264
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NR2A; GluN2A; NMDAR2A
    Orthologs
    Location:
    16 A1; 16 5.28 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (9577039..9996500, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (9577803..9992626, complement)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 1 pseudogene Neighboring gene predicted gene, 41418 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene Neighboring gene predicted gene, 30668 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    NMDA glutamate receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    contributes_to NMDA glutamate receptor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    NMDA glutamate receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NMDA glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to calcium channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cation channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    contributes_to cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to extracellular-glutamate-gated ion channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate binding ISO
    Inferred from Sequence Orthology
    more info
     
    glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ionotropic glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein dimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    scaffold protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    voltage-gated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    action potential ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
     
    NOT detection of mechanical stimulus involved in sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    directional locomotion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    excitatory postsynaptic potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    locomotory behavior TAS
    Traceable Author Statement
    more info
    PubMed 
    long-term synaptic potentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    memory ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of excitatory postsynaptic potential ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    response to wounding IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    rhythmic process ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    serotonin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    startle response IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT startle response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    NMDA selective glutamate receptor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NMDA selective glutamate receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    glutamate receptor ionotropic, NMDA 2A
    Names
    GluRepsilon1
    N-methyl D-aspartate receptor subtype 2A
    glutamate [NMDA] receptor subunit epsilon-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008170.2NP_032196.2  glutamate receptor ionotropic, NMDA 2A precursor

      See identical proteins and their annotated locations for NP_032196.2

      Status: PROVISIONAL

      Source sequence(s)
      D10217
      Consensus CDS
      CCDS27943.1
      UniProtKB/Swiss-Prot
      P35436
      Related
      ENSMUSP00000032331.6, ENSMUST00000032331.7
      Conserved Domains (5) summary
      cd06378
      Location:32392
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:458541
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:556828
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8391464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      9577039..9996500 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521794.3XP_006521857.1  glutamate receptor ionotropic, NMDA 2A isoform X1

      See identical proteins and their annotated locations for XP_006521857.1

      UniProtKB/Swiss-Prot
      P35436
      Related
      ENSMUSP00000142900.1, OTTMUSP00000017426, ENSMUST00000199708.4, OTTMUST00000038999
      Conserved Domains (5) summary
      cd06378
      Location:32392
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      COG0834
      Location:458541
      HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]
      cd13718
      Location:403802
      PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:556828
      Lig_chan; Ligand-gated ion channel
      pfam10565
      Location:8391464
      NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
    2. XM_006521795.3XP_006521858.1  glutamate receptor ionotropic, NMDA 2A isoform X2

      Conserved Domains (3) summary
      cd06378
      Location:32392
      PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family
      pfam00060
      Location:556723
      Lig_chan; Ligand-gated ion channel
      cl21456
      Location:403723
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
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