Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    Glis2 GLIS family zinc finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 83396, updated on 8-Apr-2018
    Official Symbol
    Glis2provided by MGI
    Official Full Name
    GLIS family zinc finger 2provided by MGI
    Primary source
    MGI:MGI:1932535
    See related
    Ensembl:ENSMUSG00000014303 Vega:OTTMUSG00000026679
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nkl; Gli5; Klf16
    Expression
    Broad expression in kidney adult (RPKM 54.7), ovary adult (RPKM 24.8) and 24 other tissues See more
    Orthologs
    Location:
    16 A1; 16 2.45 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (4594713..4625141)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (4594713..4615957)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene transcription factor AP4 Neighboring gene RIKEN cDNA D330022H12 gene Neighboring gene presequence translocase-asssociated motor 16 homolog (S. cerevisiae) Neighboring gene coronin 7 Neighboring gene vasorin Neighboring gene DnaJ heat shock protein family (Hsp40) member A3

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Clone Names

    • MGC36775

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    RNA polymerase II regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nervous system development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein localization to nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter involved in kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    non-motile cilium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Preferred Names
    zinc finger protein GLIS2
    Names
    GLI-Kruppel family member GLI5
    GLI-similar 2
    Kruppel-like factor 16 (neuronal)
    neuronal Krueppel-like protein
    zinc finger protein GLI5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031184.3NP_112461.2  zinc finger protein GLIS2

      See identical proteins and their annotated locations for NP_112461.2

      Status: VALIDATED

      Source sequence(s)
      AC087899, CF727873, CN703218, CX563691
      Consensus CDS
      CCDS27920.1
      UniProtKB/Swiss-Prot
      Q8VDL9
      Related
      ENSMUSP00000014447.6, OTTMUSP00000032989, ENSMUST00000014447.12, OTTMUST00000066014
      Conserved Domains (3) summary
      COG5048
      Location:233327
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      4594713..4625141
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522768.3XP_006522831.1  zinc finger protein GLIS2 isoform X1

      See identical proteins and their annotated locations for XP_006522831.1

      UniProtKB/Swiss-Prot
      Q8VDL9
      Conserved Domains (3) summary
      COG5048
      Location:233327
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:213229
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011246050.1XP_011244352.1  zinc finger protein GLIS2 isoform X4

      Conserved Domains (3) summary
      COG5048
      Location:214258
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011246048.2XP_011244350.1  zinc finger protein GLIS2 isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:214270
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011246049.1XP_011244351.1  zinc finger protein GLIS2 isoform X3

      Conserved Domains (3) summary
      COG5048
      Location:214274
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:175192
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:225246
      zf-H2C2_2; Zinc-finger double domain
    Support Center