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    Ikzf1 IKAROS family zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 22778, updated on 5-Nov-2017
    Official Symbol
    Ikzf1provided by MGI
    Official Full Name
    IKAROS family zinc finger 1provided by MGI
    Primary source
    MGI:MGI:1342540
    See related
    Ensembl:ENSMUSG00000018654 Vega:OTTMUSG00000005161
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LyF-1; hlk-1; Ikaros; Zfpn1a1; Znfn1a1; mKIAA4227; 5832432G11Rik
    Summary
    The protein encoded by this gene belongs to a family of transcription factors that are characterized by a set of four DNA-binding zinc fingers at the N-terminus and two C-terminal zinc fingers involved in protein dimerization. It is regulated by both epigenetic and transcription factors. This protein is a transcriptional regulator of hematopoietic cell development and homeostasis. In addition, it is required to confer temporal competence to retinal progenitor cells during embryogenesis, demonstrating an essential function in nervous system development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    11 A1; 11 7.02 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (11684969..11772926)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (11586216..11672929)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene predicted gene 11999 Neighboring gene fidgetin-like 1 Neighboring gene dopa decarboxylase Neighboring gene RIKEN cDNA 1700042O10 gene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA4227

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Peyer's patch development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    amacrine cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymph node development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    natural killer cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of NK T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retina development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retinal bipolar neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear pericentric heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein-DNA complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    DNA-binding protein Ikaros
    Names
    ikaros family zinc finger protein 1
    lymphoid transcription factor LyF-1
    zinc finger protein, subfamily 1A, 1 (Ikaros)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025597.2NP_001020768.1  DNA-binding protein Ikaros isoform a

      See identical proteins and their annotated locations for NP_001020768.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AK040561, AK077815, AK142856
      Consensus CDS
      CCDS24436.1
      UniProtKB/TrEMBL
      G5E8H3, Q3UQ33, Q8C5P6
      Related
      ENSMUSP00000075992.4, ENSMUST00000076700.10
      Conserved Domains (3) summary
      COG5048
      Location:144218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001301863.1NP_001288792.1  DNA-binding protein Ikaros isoform a

      See identical proteins and their annotated locations for NP_001288792.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same protein (isoform a).
      Source sequence(s)
      AK040561, AK077815, AK142856, AL596450
      Consensus CDS
      CCDS24436.1
      UniProtKB/TrEMBL
      G5E8H3, Q3UQ33, Q8C5P6
      Conserved Domains (3) summary
      COG5048
      Location:144218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001301865.1NP_001288794.1  DNA-binding protein Ikaros isoform b

      See identical proteins and their annotated locations for NP_001288794.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the coding region compared to variant 1. It encodes isoform b, which is shorter than isoform a. Both variants 2 and 4 encode the same protein (isoform b).
      Source sequence(s)
      AK040268, AK040561, AK077815, AK142856, AL596450
      Consensus CDS
      CCDS24437.1
      UniProtKB/TrEMBL
      Q3UQ33, Q5SWU0, Q8C5P6, Q8C9X3
      Conserved Domains (4) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001301866.1NP_001288795.1  DNA-binding protein Ikaros isoform c

      See identical proteins and their annotated locations for NP_001288795.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks in-frame exons in the coding region compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AK040561, AK142856, AL596450
      UniProtKB/TrEMBL
      Q3UQ33
      Conserved Domains (4) summary
      COG5048
      Location:1112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001301868.1NP_001288797.1  DNA-binding protein Ikaros isoform d

      See identical proteins and their annotated locations for NP_001288797.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform d), compared to isoform a.
      Source sequence(s)
      AK036833, AK040561, AK077815, AL596450, BB620248
      UniProtKB/TrEMBL
      Q8C5P6
      Conserved Domains (3) summary
      COG5048
      Location:143481
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    6. NM_009578.3NP_033604.2  DNA-binding protein Ikaros isoform b

      See identical proteins and their annotated locations for NP_033604.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 2 and 4 encode the same protein (isoform b).
      Source sequence(s)
      AK040268, AK040561, AK077815, AK142856, AL596450
      Consensus CDS
      CCDS24437.1
      UniProtKB/TrEMBL
      Q3UQ33, Q5SWU0, Q8C5P6, Q8C9X3
      Related
      ENSMUSP00000018798.6, OTTMUSP00000005366, ENSMUST00000018798.6, OTTMUST00000011535
      Conserved Domains (4) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      11684969..11772926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243702.1XP_011242004.1  DNA-binding protein Ikaros isoform X4

      Conserved Domains (4) summary
      COG5048
      Location:188262
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:163183
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:176200
      zf-H2C2_2; Zinc-finger double domain
      cl00514
      Location:1159
      Nitro_FMN_reductase; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are ...
    2. XM_006514680.3XP_006514743.1  DNA-binding protein Ikaros isoform X11

      Conserved Domains (3) summary
      COG5048
      Location:110184
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:85105
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:98122
      zf-H2C2_2; Zinc-finger double domain
    3. XM_011243705.1XP_011242007.1  DNA-binding protein Ikaros isoform X6

      See identical proteins and their annotated locations for XP_011242007.1

      Conserved Domains (3) summary
      COG5048
      Location:180254
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:155175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:168192
      zf-H2C2_2; Zinc-finger double domain
    4. XM_011243709.1XP_011242011.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242011.1

      UniProtKB/TrEMBL
      Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:164238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    5. XM_011243711.1XP_011242013.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242013.1

      UniProtKB/TrEMBL
      Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:164238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    6. XM_006514682.2XP_006514745.1  DNA-binding protein Ikaros isoform X15

      See identical proteins and their annotated locations for XP_006514745.1

      Conserved Domains (5) summary
      COG5048
      Location:25155
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:84104
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:82104
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:96121
      zf-H2C2_2; Zinc-finger double domain
      cl00514
      Location:1159
      Nitro_FMN_reductase; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are ...
    7. XM_011243701.2XP_011242003.1  DNA-binding protein Ikaros isoform X2

      Conserved Domains (3) summary
      COG5048
      Location:163501
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    8. XM_011243700.2XP_011242002.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242002.1

      UniProtKB/TrEMBL
      Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:164238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    9. XM_011243707.2XP_011242009.1  DNA-binding protein Ikaros isoform X8

      Conserved Domains (3) summary
      COG5048
      Location:163466
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    10. XM_011243706.2XP_011242008.1  DNA-binding protein Ikaros isoform X7

      Conserved Domains (2) summary
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    11. XM_011243703.2XP_011242005.1  DNA-binding protein Ikaros isoform X5

      See identical proteins and their annotated locations for XP_011242005.1

      Conserved Domains (3) summary
      COG5048
      Location:143481
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    12. XM_011243713.2XP_011242015.1  DNA-binding protein Ikaros isoform X10

      Conserved Domains (3) summary
      COG5048
      Location:164219
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    13. XM_006514676.3XP_006514739.1  DNA-binding protein Ikaros isoform X3

      See identical proteins and their annotated locations for XP_006514739.1

      UniProtKB/TrEMBL
      G5E8H3
      Conserved Domains (3) summary
      COG5048
      Location:144218
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    14. XM_011243712.2XP_011242014.1  DNA-binding protein Ikaros isoform X9

      Conserved Domains (2) summary
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    15. XM_011243714.2XP_011242016.1  DNA-binding protein Ikaros isoform X12

      Conserved Domains (3) summary
      COG5048
      Location:144199
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:119139
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:132156
      zf-H2C2_2; Zinc-finger double domain
    16. XM_011243715.1XP_011242017.1  DNA-binding protein Ikaros isoform X13

      See identical proteins and their annotated locations for XP_011242017.1

      UniProtKB/TrEMBL
      Q5SWU0
      Conserved Domains (4) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    17. XM_011243716.1XP_011242018.1  DNA-binding protein Ikaros isoform X14

      Conserved Domains (4) summary
      COG5048
      Location:1131
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    18. XM_011243717.1XP_011242019.1  DNA-binding protein Ikaros isoform X16

      See identical proteins and their annotated locations for XP_011242019.1

      UniProtKB/TrEMBL
      Q3UQ33
      Conserved Domains (4) summary
      COG5048
      Location:1112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    19. XM_011243718.1XP_011242020.1  DNA-binding protein Ikaros isoform X17

      Conserved Domains (4) summary
      COG5048
      Location:1112
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:6080
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:5880
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:7297
      zf-H2C2_2; Zinc-finger double domain
    20. XM_011243704.1XP_011242006.1  DNA-binding protein Ikaros isoform X6

      See identical proteins and their annotated locations for XP_011242006.1

      Conserved Domains (3) summary
      COG5048
      Location:180254
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:155175
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:168192
      zf-H2C2_2; Zinc-finger double domain
    21. XM_011243708.1XP_011242010.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242010.1

      UniProtKB/TrEMBL
      Q5SWT9
      Related
      ENSMUSP00000067372.5, OTTMUSP00000005365, ENSMUST00000065433.11, OTTMUST00000011534
      Conserved Domains (3) summary
      COG5048
      Location:164238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
    22. XM_011243710.2XP_011242012.1  DNA-binding protein Ikaros isoform X1

      See identical proteins and their annotated locations for XP_011242012.1

      UniProtKB/TrEMBL
      Q5SWT9
      Conserved Domains (3) summary
      COG5048
      Location:164238
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:152176
      zf-H2C2_2; Zinc-finger double domain
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