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    ROR1 receptor tyrosine kinase like orphan receptor 1 [ Homo sapiens (human) ]

    Gene ID: 4919, updated on 19-May-2018
    Official Symbol
    ROR1provided by HGNC
    Official Full Name
    receptor tyrosine kinase like orphan receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:10256
    See related
    Ensembl:ENSG00000185483 MIM:602336; Vega:OTTHUMG00000009022
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTRKR1; dJ537F10.1
    Summary
    This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
    Expression
    Ubiquitous expression in lung (RPKM 2.7), endometrium (RPKM 2.2) and 23 other tissues See more
    Orthologs
    See ROR1 in Genome Data Viewer
    Location:
    1p31.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (63774019..64181498)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (64239690..64647181)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphoglucomutase 1 Neighboring gene uncharacterized LOC105378771 Neighboring gene RNA, 7SL, cytoplasmic 130, pseudogene Neighboring gene ribosomal protein L19 pseudogene 3 Neighboring gene cofilin 1 pseudogene 3 Neighboring gene uncharacterized LOC105378772 Neighboring gene RNA, U6 small nuclear 809, pseudogene Neighboring gene ROR1 antisense RNA 1 Neighboring gene uncharacterized LOC105378773 Neighboring gene ubiquitin conjugating enzyme E2 U

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Beta-catenin independent WNT signaling, organism-specific biosystem (from REACTOME)
      Beta-catenin independent WNT signaling, organism-specific biosystemHumans and mice have 19 identified WNT proteins that were originally classified as either 'canonical' or 'non-canonical' depending upon whether they were able to transform the mouse mammary epithelia...
    • Nuclear Receptors, organism-specific biosystem (from WikiPathways)
      Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
    • PCP/CE pathway, organism-specific biosystem (from REACTOME)
      PCP/CE pathway, organism-specific biosystemThe planar cell polarity (PCP) pathway controls the establishment of polarity within the plane of a sheet of cells. PCP was initially characterized in Drosophila, where it controls the arrangement o...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemWNT signaling pathways control a wide range of developmental and adult process in metozoans including cell proliferation, cell fate decisions, cell polarity and stem cell maintenance (reviewed in Sai...
    • WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystem (from REACTOME)
      WNT5A-dependent internalization of FZD2, FZD5 and ROR2, organism-specific biosystemInternalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2...
    • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt Signaling Pathway Netpath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway Netpath, organism-specific biosystemWNT signal, through the canonical pathway, controls cell fate determination and through the non-canonical pathway controls cell movement and tissue polarity. The name "wnt" is a fusion of two terms, ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC99659

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-activated receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    mitogen-activated protein kinase kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transmembrane receptor protein tyrosine kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway, planar cell polarity pathway IEA
    Inferred from Electronic Annotation
    more info
     
    astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    inner ear development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-tyrosine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    axon terminus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    inactive tyrosine-protein kinase transmembrane receptor ROR1
    Names
    neurotrophic tyrosine kinase, receptor-related 1
    NP_001077061.1
    NP_005003.2
    XP_011539828.1
    XP_016856865.1
    XP_016856866.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032801.2 RefSeqGene

      Range
      5001..412480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083592.1NP_001077061.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001077061.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 3' UTR and lacks an in-frame portion of the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter C-terminus that lacks a tyrosine kinase catalytic domain, compared to isoform 1.
      Source sequence(s)
      AL137859, AL445205, BC080541
      Consensus CDS
      CCDS41344.1
      UniProtKB/Swiss-Prot
      Q01973
      Related
      ENSP00000360121.1, OTTHUMP00000010574, ENST00000371080.5, OTTHUMT00000025003
      Conserved Domains (3) summary
      cd07467
      Location:166307
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:311392
      KR; Kringle domain
      smart00410
      Location:66148
      IG_like; Immunoglobulin like
    2. NM_005012.3NP_005003.2  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_005003.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK000776, AK308088, AL137859, AL445205, M97675
      Consensus CDS
      CCDS626.1
      UniProtKB/Swiss-Prot
      Q01973
      Related
      ENSP00000360120.1, OTTHUMP00000010573, ENST00000371079.5, OTTHUMT00000025002
      Conserved Domains (4) summary
      cd07467
      Location:166307
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:311393
      KR; Kringle domain
      smart00410
      Location:66148
      IG_like; Immunoglobulin like
      cd05090
      Location:467749
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      63774019..64181498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017001377.1XP_016856866.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      Conserved Domains (6) summary
      cd00096
      Location:1280
      Ig; Immunoglobulin domain
      cd07467
      Location:103244
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:248330
      KR; Kringle domain
      smart00410
      Location:385
      IG_like; Immunoglobulin like
      cd05090
      Location:404686
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
      pfam07714
      Location:410683
      Pkinase_Tyr; Protein tyrosine kinase
    2. XM_011541526.1XP_011539828.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X2

      See identical proteins and their annotated locations for XP_011539828.1

      Related
      ENSP00000441637.2, ENST00000545203.2
      Conserved Domains (6) summary
      cd00096
      Location:1280
      Ig; Immunoglobulin domain
      cd07467
      Location:103244
      CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1
      smart00130
      Location:248330
      KR; Kringle domain
      smart00410
      Location:385
      IG_like; Immunoglobulin like
      cd05090
      Location:404686
      PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1
      pfam07714
      Location:410683
      Pkinase_Tyr; Protein tyrosine kinase
    3. XM_017001376.1XP_016856865.1  inactive tyrosine-protein kinase transmembrane receptor ROR1 isoform X1

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