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    Slc26a5 solute carrier family 26, member 5 [ Mus musculus (house mouse) ]

    Gene ID: 80979, updated on 28-May-2017
    Official Symbol
    Slc26a5provided by MGI
    Official Full Name
    solute carrier family 26, member 5provided by MGI
    Primary source
    MGI:MGI:1933154
    See related
    Ensembl:ENSMUSG00000029015 Vega:OTTMUSG00000023668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pres; prestin
    Orthologs
    Location:
    5 A3; 5 9.97 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (21809001..21865604, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (21316473..21371422, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase 2 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene reelin Neighboring gene DnaJ heat shock protein family (Hsp40) member A1, pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Clone Names

    • MGC124328, MGC124329

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    anion:anion antiporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    spectrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    anion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    bicarbonate transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    fructose transport ISO
    Inferred from Sequence Orthology
    more info
     
    ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    protein tetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of intracellular pH IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
     
    sulfate transport IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    prestin
    Names
    outer hair cell motor protein
    prestin (motor protein)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289787.1NP_001276716.1  prestin isoform 2

      See identical proteins and their annotated locations for NP_001276716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AC113028, AC125313, AY024359, CJ076475
      Consensus CDS
      CCDS71547.1
      UniProtKB/Swiss-Prot
      Q99NH7
      UniProtKB/TrEMBL
      Q32MT6
      Related
      ENSMUSP00000110830.1, OTTMUSP00000027909, ENSMUST00000115176.7, OTTMUST00000057764
      Conserved Domains (3) summary
      cd07042
      Location:489657
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      cd07043
      Location:552646
      STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
      TIGR00815
      Location:66672
      sulP; high affinity sulphate transporter 1
    2. NM_001289788.1NP_001276717.1  prestin isoform 3

      See identical proteins and their annotated locations for NP_001276717.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 3, which is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC113028, AC125313, AY024359, CJ076475
      UniProtKB/Swiss-Prot
      Q99NH7
      UniProtKB/TrEMBL
      Q32MT7
      Conserved Domains (3) summary
      cd07042
      Location:260428
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      cd07043
      Location:323417
      STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
      TIGR00815
      Location:5443
      sulP; high affinity sulphate transporter 1
    3. NM_030727.5NP_109652.3  prestin isoform 1

      See identical proteins and their annotated locations for NP_109652.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC113028, AC125313, AY024359, CJ076475
      Consensus CDS
      CCDS19109.1
      UniProtKB/Swiss-Prot
      Q99NH7
      Related
      ENSMUSP00000030878.1, OTTMUSP00000027908, ENSMUST00000030878.7, OTTMUST00000057763
      Conserved Domains (3) summary
      cd07042
      Location:526694
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      cd07043
      Location:589683
      STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
      TIGR00815
      Location:66709
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      21809001..21865604 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535818.1XP_006535881.1  prestin isoform X1

      Conserved Domains (3) summary
      cd07042
      Location:464632
      STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function
      cd07043
      Location:527621
      STAS_anti-anti-sigma_factors; Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation
      TIGR00815
      Location:4647
      sulP; high affinity sulphate transporter 1
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