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    MEIS1 Meis homeobox 1 [ Homo sapiens (human) ]

    Gene ID: 4211, updated on 9-Jul-2017
    Official Symbol
    MEIS1provided by HGNC
    Official Full Name
    Meis homeobox 1provided by HGNC
    Primary source
    HGNC:HGNC:7000
    See related
    Ensembl:ENSG00000143995 MIM:601739; Vega:OTTHUMG00000150714
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Homeobox genes, of which the most well-characterized category is represented by the HOX genes, play a crucial role in normal development. In addition, several homeoproteins are involved in neoplasia. This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2p14
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (66435125..66572765)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (66662257..66799891)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1873 Neighboring gene MEIS1 antisense RNA 3 Neighboring gene MEIS1 antisense RNA 2 Neighboring gene long intergenic non-protein coding RNA 1798 Neighboring gene long intergenic non-protein coding RNA 1797

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genetic determinants of P wave duration and PR segment.
    NHGRI GWA Catalog
    Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
    NHGRI GWA Catalog
    Genome-wide association studies of the PR interval in African Americans.
    NHGRI GWA Catalog
    Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.
    NHGRI GWA Catalog
    Genome-wide association study of PR interval.
    NHGRI GWA Catalog
    Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.
    NHGRI GWA Catalog
    Genome-wide diet-gene interaction analyses for risk of colorectal cancer.
    NHGRI GWA Catalog
    Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC43380

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
     
    lens morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
     
    megakaryocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    transcription factor complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    homeobox protein Meis1
    Names
    Meis1, myeloid ecotropic viral integration site 1 homolog
    WUGSC:H_NH0444B04.1
    leukemogenic homolog protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011467.1 RefSeqGene

      Range
      5001..142360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002398.2NP_002389.1  homeobox protein Meis1

      See identical proteins and their annotated locations for NP_002389.1

      Status: REVIEWED

      Source sequence(s)
      AI203963, AL832770, BC043503, CB854199, U85707
      Consensus CDS
      CCDS46309.1
      UniProtKB/Swiss-Prot
      O00470
      Related
      ENSP00000272369.8, OTTHUMP00000198324, ENST00000272369.13, OTTHUMT00000319725
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      66435125..66572765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017004141.1XP_016859630.1  homeobox protein Meis1 isoform X3

    2. XM_005264323.2XP_005264380.1  homeobox protein Meis1 isoform X5

      See identical proteins and their annotated locations for XP_005264380.1

      Conserved Domains (2) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:124207
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    3. XM_005264321.2XP_005264378.1  homeobox protein Meis1 isoform X1

      See identical proteins and their annotated locations for XP_005264378.1

      Conserved Domains (2) summary
      pfam05920
      Location:306345
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:124207
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    4. XM_017004144.1XP_016859633.1  homeobox protein Meis1 isoform X9

      Conserved Domains (2) summary
      pfam05920
      Location:146185
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:147
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    5. XM_017004142.1XP_016859631.1  homeobox protein Meis1 isoform X4

      Related
      ENSP00000454209.1, OTTHUMP00000247942, ENST00000560281.6, OTTHUMT00000417510
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    6. XM_005264322.2XP_005264379.1  homeobox protein Meis1 isoform X2

      See identical proteins and their annotated locations for XP_005264379.1

      Related
      ENSP00000381518.2, OTTHUMP00000198326, ENST00000398506.6, OTTHUMT00000319727
      Conserved Domains (2) summary
      pfam05920
      Location:290329
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:108191
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    7. XM_017004146.1XP_016859635.1  homeobox protein Meis1 isoform X10

      Conserved Domains (2) summary
      pfam05920
      Location:146185
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:147
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    8. XM_017004145.1XP_016859634.1  homeobox protein Meis1 isoform X9

      Conserved Domains (2) summary
      pfam05920
      Location:146185
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:147
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    9. XM_017004143.1XP_016859632.1  homeobox protein Meis1 isoform X7

    10. XM_005264325.4XP_005264382.1  homeobox protein Meis1 isoform X8

      See identical proteins and their annotated locations for XP_005264382.1

      UniProtKB/TrEMBL
      F5GYS8
      Related
      ENSP00000440571.1, OTTHUMP00000247943, ENST00000495021.6, OTTHUMT00000417511
      Conserved Domains (2) summary
      pfam05920
      Location:225264
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:43126
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1
    11. XM_005264324.4XP_005264381.1  homeobox protein Meis1 isoform X6

      See identical proteins and their annotated locations for XP_005264381.1

      Conserved Domains (2) summary
      pfam05920
      Location:225264
      Homeobox_KN; Homeobox KN domain
      pfam16493
      Location:43126
      Meis_PKNOX_N; N-terminal of Homeobox Meis and PKNOX1

    RNA

    1. XR_001738744.1 RNA Sequence

    2. XR_244932.2 RNA Sequence

    3. XR_244933.2 RNA Sequence

    4. XR_001738746.1 RNA Sequence

    5. XR_001738745.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      66593726..66731071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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