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    ENPEP glutamyl aminopeptidase [ Homo sapiens (human) ]

    Gene ID: 2028, updated on 22-Apr-2017
    Official Symbol
    ENPEPprovided by HGNC
    Official Full Name
    glutamyl aminopeptidaseprovided by HGNC
    Primary source
    HGNC:HGNC:3355
    See related
    Ensembl:ENSG00000138792 MIM:138297; Vega:OTTHUMG00000132546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APA; CD249; gp160
    Orthologs
    Location:
    4q25
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (110476073..110563337)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (111397229..111484493)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 like 1 pseudogene 13 Neighboring gene zinc finger protein 969, pseudogene Neighboring gene PITX2 adjacent non-coding RNA Neighboring gene paired like homeodomain 2

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Human metabolic individuality in biomedical and pharmaceutical research.
    NHGRI GWA Catalog
    Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
    NHGRI GWA Catalog
    Variants conferring risk of atrial fibrillation on chromosome 4q25.
    NHGRI GWA Catalog
    • Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystem (from REACTOME)
      Metabolism of Angiotensinogen to Angiotensins, organism-specific biosystemAngiotensinogen, a prohormone, is synthesized and secreted mainly by the liver but also from other tissues (reviewed in Fyhrquist and Saijonmaa 2008, Cat and Touyz 2011). Renin, an aspartyl protease ...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
      Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
    • Renin-angiotensin system, organism-specific biosystem (from KEGG)
      Renin-angiotensin system, organism-specific biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    • Renin-angiotensin system, conserved biosystem (from KEGG)
      Renin-angiotensin system, conserved biosystemThe renin-angiotensin system (RAS) is a peptidergic system with endocrine characteristics regarding to the regulation of the blood pressure and hydro-electrolytic balance. In the classical RAS, the ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloaminopeptidase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    metallopeptidase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    angiotensin catabolic process in blood NAS
    Non-traceable Author Statement
    more info
    PubMed 
    angiotensin maturation TAS
    Traceable Author Statement
    more info
     
    cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    glomerulus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    regulation of systemic arterial blood pressure by renin-angiotensin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of systemic arterial blood pressure by renin-angiotensin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    apical part of cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    brush border ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    external side of plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    glutamyl aminopeptidase
    Names
    AP-A
    EAP
    aminopeptidase A
    differentiation antigen gp160
    NP_001968.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001977.3NP_001968.3  glutamyl aminopeptidase

      See identical proteins and their annotated locations for NP_001968.3

      Status: VALIDATED

      Source sequence(s)
      AC098798, AI640493, AL568777, BC094770, BG400415, DB070526
      Consensus CDS
      CCDS3691.1
      UniProtKB/Swiss-Prot
      Q07075
      Related
      ENSP00000265162.5, OTTHUMP00000163369, ENST00000265162.9, OTTHUMT00000255747
      Conserved Domains (3) summary
      cd09601
      Location:100545
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:92482
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:617931
      ERAP1_C; ERAP1-like C-terminal domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      110476073..110563337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017007877.1XP_016863366.1  glutamyl aminopeptidase isoform X1

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      111373917..111461184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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