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    IL13 interleukin 13 [ Homo sapiens (human) ]

    Gene ID: 3596, updated on 12-Mar-2017
    Official Symbol
    IL13provided by HGNC
    Official Full Name
    interleukin 13provided by HGNC
    Primary source
    HGNC:HGNC:5973
    See related
    Ensembl:ENSG00000169194 MIM:147683; Vega:OTTHUMG00000059723
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P600; IL-13
    Summary
    This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5q31.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 5 NC_000005.10 (132658173..132661109)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131993865..131996801)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene interleukin 5 Neighboring gene RAD50 double strand break repair protein Neighboring gene T helper type 2 locus control region associated RNA Neighboring gene uncharacterized LOC105379176 Neighboring gene interleukin 4 Neighboring gene kinesin family member 3A

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Allergic rhinitis
    MedGen: C2607914 OMIM: 607154 GeneReviews: Not available
    Compare labs
    Asthma, susceptibility to
    MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    NHGRI GWA Catalog
    A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
    NHGRI GWA Catalog
    A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.
    NHGRI GWA Catalog
    A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study.
    NHGRI GWA Catalog
    A large-scale, consortium-based genomewide association study of asthma.
    NHGRI GWA Catalog
    A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus.
    NHGRI GWA Catalog
    Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.
    NHGRI GWA Catalog
    Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.
    NHGRI GWA Catalog
    Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 induces release of IL-13 in CD4+ T cells PubMed
    env HIV-1 gp120 induces IL-4 and IL-13 releases from human basophils through its interaction with the VH3 region of IgE PubMed
    env HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-13 in peptide-treated PBMCs PubMed
    Tat tat HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network PubMed
    reverse transcriptase gag-pol IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions PubMed

    Go to the HIV-1, Human Interaction Database

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    • Fc epsilon RI signaling pathway, conserved biosystem (from KEGG)
      Fc epsilon RI signaling pathway, conserved biosystemFc epsilon RI-mediated signaling pathways in mast cells are initiated by the interaction of antigen (Ag) with IgE bound to the extracellular domain of the alpha chain of Fc epsilon RI. The activation...
    • Glucocorticoid receptor regulatory network, organism-specific biosystem (from Pathway Interaction Database)
      Glucocorticoid receptor regulatory network, organism-specific biosystem
      Glucocorticoid receptor regulatory network
    • IL-17 signaling pathway, organism-specific biosystem (from KEGG)
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      IL12 signaling mediated by STAT4
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
      Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
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    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC116786, MGC116788, MGC116789

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    interleukin-13 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell signaling IC
    Inferred by Curator
    more info
    PubMed 
    cellular response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    immune response IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    movement of cell or subcellular component TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of NAD(P)H oxidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of complement-dependent cytotoxicity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of lung ciliated cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of neuron death IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transforming growth factor beta production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of connective tissue growth factor production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of lung goblet cell differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of pancreatic stellate cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of release of sequestered calcium ion into cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of tyrosine phosphorylation of Stat6 protein IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of proton transport IEA
    Inferred from Electronic Annotation
    more info
     
    response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012090.1 RefSeqGene

      Range
      5001..7937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002188.2NP_002179.2  interleukin-13 precursor

      See identical proteins and their annotated locations for NP_002179.2

      Status: REVIEWED

      Source sequence(s)
      X69079
      Consensus CDS
      CCDS4157.1
      UniProtKB/Swiss-Prot
      P35225
      Related
      ENSP00000304915, OTTHUMP00000066048, ENST00000304506, OTTHUMT00000132782
      Conserved Domains (1) summary
      pfam03487
      Location:35144
      IL13; Interleukin-13

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p7 Primary Assembly

      Range
      132658173..132661109
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018916.2 Alternate CHM1_1.1

      Range
      131427162..131430098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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