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    Atg7 Autophagy-related 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37141, updated on 18-Jul-2017
    Official Symbol
    Atg7provided by FlyBase
    Official Full Name
    Autophagy-related 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0034366
    Locus tag
    Dmel_CG5489
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    atg-7; atg7; ATG7; CG5489; Dmel\CG5489
    Location:
    55E2-55E2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18620466..18625044, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14507971..14512549, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene CG5323 gene product from transcript CG5323-RA Neighboring gene CG5327 gene product from transcript CG5327-RA Neighboring gene CG5493 gene product from transcript CG5493-RB Neighboring gene CG5335 gene product from transcript CG5335-RA Neighboring gene Secretory 6 Neighboring gene CG5345 gene product from transcript CG5345-RB

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    Atg12 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Atg8 activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Atg8 activating enzyme activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT ubiquitin activating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    C-terminal protein lipidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    autophagy of mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    catabolic autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    catabolic autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT larval midgut cell programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of cell death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein lipidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein modification by small protein conjugation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein modification by small protein conjugation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of catabolic autophagy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of hemopoiesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    pre-autophagosomal structure ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    CG5489 gene product from transcript CG5489-RB
    Names
    Atg7-PA
    Atg7-PB
    Autophagy-related 7
    Autophagy-specific gene 7
    CG5489-PA
    CG5489-PB
    autophagy-related gene 7
    autophagy-related protein 7

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18620466..18625044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166298.3NP_725809.1  Autophagy-related 7, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725809.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1ZBA9
      Related
      FBpp0085890, FBtr0086711
      Conserved Domains (2) summary
      cd01486
      Location:167484
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      pfam16420
      Location:968
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
    2. NM_137506.4NP_611350.1  Autophagy-related 7, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611350.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JY94
      Related
      FBpp0085891, FBtr0086712
      Conserved Domains (3) summary
      cd01486
      Location:341658
      Apg7; Apg7 is an E1-like protein, that activates two different ubiquitin-like proteins, Apg12 and Apg8, and assigns them to specific E2 enzymes, Apg10 and Apg3, respectively. This leads to the covalent conjugation of Apg8 with phosphatidylethanolamine, an ...
      TIGR01381
      Location:11682
      E1_like_apg7; E1-like protein-activating enzyme Gsa7p/Apg7p
      pfam16420
      Location:9303
      ATG7_N; Ubiquitin-like modifier-activating enzyme ATG7 N-terminus
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