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    ACSL3 acyl-CoA synthetase long chain family member 3 [ Homo sapiens (human) ]

    Gene ID: 2181, updated on 22-Jun-2017
    Official Symbol
    ACSL3provided by HGNC
    Official Full Name
    acyl-CoA synthetase long chain family member 3provided by HGNC
    Primary source
    HGNC:HGNC:3570
    See related
    Ensembl:ENSG00000123983 MIM:602371; Vega:OTTHUMG00000133160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS3; FACL3; PRO2194
    Summary
    The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    2q36.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 2 NC_000002.12 (222860984..222944624)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223725732..223808119)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373903 Neighboring gene ribosomal protein L31 pseudogene 17 Neighboring gene uncharacterized LOC105373904 Neighboring gene autophagy related 12 pseudogene 2 Neighboring gene zinc finger protein 79 pseudogene Neighboring gene potassium voltage-gated channel subfamily E regulatory subunit 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify acyl-CoA synthetase long-chain family member 3 (ACSL3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with acyl-CoA synthetase long-chain family member 3 (ACSL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    decanoate--CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid-CoA ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    long-chain fatty acid-CoA ligase activity TAS
    Traceable Author Statement
    more info
     
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    brain development IEA
    Inferred from Electronic Annotation
    more info
     
    fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty acid import IDA
    Inferred from Direct Assay
    more info
    PubMed 
    long-chain fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    long-chain fatty-acyl-CoA biosynthetic process TAS
    Traceable Author Statement
    more info
     
    positive regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of phosphatidylcholine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    very-low-density lipoprotein particle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    long-chain-fatty-acid--CoA ligase 3
    Names
    LACS 3
    fatty-acid-Coenzyme A ligase, long-chain 3
    lignoceroyl-CoA synthase
    long-chain acyl-CoA synthetase 3
    NP_004448.2
    NP_976251.1
    XP_016859073.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004457.3NP_004448.2  long-chain-fatty-acid--CoA ligase 3

      See identical proteins and their annotated locations for NP_004448.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI378485, AK001471, BC041692, BF679686, BG772246, BM971377, N44998
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573
      UniProtKB/TrEMBL
      A0A024R497, B3KMA6
      Related
      ENSP00000350012.3, OTTHUMP00000164212, ENST00000357430.7, OTTHUMT00000256862
      Conserved Domains (2) summary
      cd05927
      Location:130717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:30717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein
    2. NM_203372.1NP_976251.1  long-chain-fatty-acid--CoA ligase 3

      See identical proteins and their annotated locations for NP_976251.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI378485, AK001471, BC041692, BF679686, BM971377, BQ435549, BX472576, N44998
      Consensus CDS
      CCDS2455.1
      UniProtKB/Swiss-Prot
      O95573
      UniProtKB/TrEMBL
      A0A024R497, B3KMA6
      Related
      ENSP00000375918.3, OTTHUMP00000203810, ENST00000392066.7, OTTHUMT00000331001
      Conserved Domains (2) summary
      cd05927
      Location:130717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:30717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p7 Primary Assembly

      Range
      222860984..222944624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017003584.1XP_016859073.1  long-chain-fatty-acid--CoA ligase 3 isoform X1

      UniProtKB/Swiss-Prot
      O95573
      UniProtKB/TrEMBL
      A0A024R497
      Conserved Domains (2) summary
      cd05927
      Location:130717
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
      PLN02387
      Location:30717
      PLN02387; long-chain-fatty-acid-CoA ligase family protein

    RNA

    1. XR_001738666.1 RNA Sequence

    2. XR_001738667.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      223732626..223813632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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