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    S100A11 S100 calcium binding protein A11 [ Homo sapiens (human) ]

    Gene ID: 6282, updated on 8-Apr-2018
    Official Symbol
    S100A11provided by HGNC
    Official Full Name
    S100 calcium binding protein A11provided by HGNC
    Primary source
    HGNC:HGNC:10488
    See related
    Ensembl:ENSG00000163191 MIM:603114; Vega:OTTHUMG00000013069
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MLN70; S100C; HEL-S-43
    Summary
    The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in esophagus (RPKM 707.5), placenta (RPKM 273.6) and 20 other tissues See more
    Orthologs
    Location:
    1q21.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (152032506..152037035, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152004982..152009511, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371441 Neighboring gene S100 calcium binding protein A10 Neighboring gene uncharacterized LOC105371442 Neighboring gene NBPF member 18, pseudogene Neighboring gene uncharacterized LOC101927949 Neighboring gene S100A11-TCHHL1 intergenic CAGE-defined high expression enhancer Neighboring gene serine palmitoyltransferase long chain base subunit 1 pseudogene 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
      Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    S100 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cadherin binding involved in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of DNA replication TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    neutrophil degranulation TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular exosome HDA PubMed 
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space HDA PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule lumen TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    protein S100-A11
    Names
    MLN 70
    calgizzarin
    epididymis secretory protein Li 43
    metastatic lymph node gene 70 protein
    protein S100-C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005620.1NP_005611.1  protein S100-A11

      See identical proteins and their annotated locations for NP_005611.1

      Status: REVIEWED

      Source sequence(s)
      D38583
      Consensus CDS
      CCDS1009.1
      UniProtKB/Swiss-Prot
      P31949
      UniProtKB/TrEMBL
      V9HWH9
      Related
      ENSP00000271638.2, OTTHUMP00000015271, ENST00000271638.2, OTTHUMT00000036676
      Conserved Domains (1) summary
      cd05023
      Location:795
      S-100A11; S-100A11: S-100A11 domain found in proteins similar to S100A11. S100A11 is a member of the S-100 domain family within EF-hand Ca2+-binding proteins superfamily. Note that the S-100 hierarchy, to which this S-100A11 group belongs, contains only S-100 ...

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

      Range
      152032506..152037035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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