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    Gsn gelsolin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296654, updated on 22-Apr-2017
    Official Symbol
    Gsnprovided by RGD
    Official Full Name
    gelsolinprovided by RGD
    Primary source
    RGD:1303089
    See related
    Ensembl:ENSRNOG00000018991
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    plays a role in phosphoinositide mediated disassembly of actin filaments in Sertoli cell adhesion complexes; may regulate sperm release and turnover of the blood-testis barrier [RGD, Feb 2006]
    Orthologs
    Location:
    3p11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (14456106..14508922)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 3 NC_005102.3 (19773655..19826463)

    Chromosome 3 - NC_005102.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548763 Neighboring gene uncharacterized LOC102554040 Neighboring gene 40S ribosomal protein S29 pseudogene Neighboring gene stomatin Neighboring gene glycoprotein, alpha-galactosyltransferase 1-like 1

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC95032

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    myosin II binding IEA
    Inferred from Electronic Annotation
    more info
     
    myosin II binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin filament reorganization IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin filament severing ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament severing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    actin polymerization or depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    amyloid fibril formation IEA
    Inferred from Electronic Annotation
    more info
     
    amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    barbed-end actin filament capping IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to cadmium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cilium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    hepatocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    oligodendrocyte development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    phagocytosis, engulfment IEA
    Inferred from Electronic Annotation
    more info
     
    phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of actin nucleation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of keratinocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein processing in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein processing in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    protein destabilization IEA
    Inferred from Electronic Annotation
    more info
     
    protein destabilization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of establishment of T cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment of T cell polarity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of plasma membrane raft polarization IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of plasma membrane raft polarization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of podosome assembly IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor clustering IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of receptor clustering ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of wound healing, spreading of epidermal cells IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    renal protein absorption IEA
    Inferred from Electronic Annotation
    more info
     
    renal protein absorption ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    sequestering of actin monomers IEA
    Inferred from Electronic Annotation
    more info
     
    sequestering of actin monomers ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle atrophy IEA
    Inferred from Electronic Annotation
    more info
     
    striated muscle atrophy ISO
    Inferred from Sequence Orthology
    more info
     
    tissue regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
     
    wound healing IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cap IEA
    Inferred from Electronic Annotation
    more info
     
    actin cap ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    blood microparticle IEA
    Inferred from Electronic Annotation
    more info
     
    blood microparticle ISO
    Inferred from Sequence Orthology
    more info
     
    cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    podosome IEA
    Inferred from Electronic Annotation
    more info
     
    podosome ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    sarcoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    gelsolin
    Names
    ADF
    actin-depolymerizing factor
    brevin

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004080.1NP_001004080.1  gelsolin precursor

      See identical proteins and their annotated locations for NP_001004080.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079472
      UniProtKB/Swiss-Prot
      Q68FP1
      Related
      ENSRNOP00000025857.5, ENSRNOT00000025857.5
      Conserved Domains (6) summary
      cd11288
      Location:559647
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:184273
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:57169
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:664762
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:296393
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:437537
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005102.4 Reference Rnor_6.0 Primary Assembly

      Range
      14456106..14508922
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017591662.1XP_017447151.1  gelsolin isoform X1

      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:258355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    2. XM_006234040.2XP_006234102.1  gelsolin isoform X2

      UniProtKB/Swiss-Prot
      Q68FP1
      Related
      ENSRNOP00000075631.1, ENSRNOT00000078939.1
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:247344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    Alternate Rn_Celera

    Genomic

    1. AC_000071.1 Alternate Rn_Celera

      Range
      13325045..13351501
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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