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    Foxa2 forkhead box A2 [ Mus musculus (house mouse) ]

    Gene ID: 15376, updated on 16-May-2017
    Official Symbol
    Foxa2provided by MGI
    Official Full Name
    forkhead box A2provided by MGI
    Primary source
    MGI:MGI:1347476
    See related
    Ensembl:ENSMUSG00000037025 Vega:OTTMUSG00000015678
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hnf3b; Tcf3b; Hnf-3b; Tcf-3b; HNF3beta; HNF3-beta
    Orthologs
    Location:
    2 G3; 2 73.38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (148042877..148046969, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (147868614..147872705, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35579 Neighboring gene predicted gene, 46769 Neighboring gene RIKEN cDNA 9030622O22 gene Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene predicted gene, 36597

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    core promoter binding TAS
    Traceable Author Statement
    more info
    PubMed 
    double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcription regulatory region DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure formation involved in morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    anatomical structure morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    anterior/posterior pattern specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell differentiation in hindbrain IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell differentiation in hindbrain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    connective tissue development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopaminergic neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    dorsal/ventral neural tube patterning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dorsal/ventral neural tube patterning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ectoderm formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocrine pancreas development ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial tube branching involved in lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung epithelial cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of detection of glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter by glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter by glucose IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase III promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    primitive streak formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of insulin secretion involved in cellular response to glucose stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of steroid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of steroid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    response to interleukin-6 TAS
    Traceable Author Statement
    more info
    PubMed 
    signal transduction involved in regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    somite rostral/caudal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    hepatocyte nuclear factor 3-beta
    Names
    HNF-3-beta
    forkhead box protein A2
    hepatocyte nuclear factor 3 beta (winged helix transcription factor)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291065.1NP_001277994.1  hepatocyte nuclear factor 3-beta isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL845297, L10409
      Consensus CDS
      CCDS71157.1
      UniProtKB/Swiss-Prot
      P35583
      UniProtKB/TrEMBL
      G5E8P5
      Related
      ENSMUSP00000105590.1, OTTMUSP00000016694, ENSMUST00000109964.7, OTTMUST00000037260
      Conserved Domains (4) summary
      smart00339
      Location:165253
      FH; FORKHEAD
      pfam08430
      Location:23164
      Forkhead_N; Forkhead N-terminal region
      pfam09354
      Location:381454
      HNF_C; HNF3 C-terminal domain
      pfam16056
      Location:224319
      DUF4799; Domain of unknown function (DUF4799)
    2. NM_001291067.1NP_001277996.1  hepatocyte nuclear factor 3-beta isoform c

      See identical proteins and their annotated locations for NP_001277996.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL845297, BU055166
      Conserved Domains (4) summary
      smart00339
      Location:129217
      FH; FORKHEAD
      pfam08430
      Location:1128
      Forkhead_N; Forkhead N-terminal region
      pfam09354
      Location:345418
      HNF_C; HNF3 C-terminal domain
      pfam16056
      Location:188283
      DUF4799; Domain of unknown function (DUF4799)
    3. NM_010446.3NP_034576.2  hepatocyte nuclear factor 3-beta isoform b

      See identical proteins and their annotated locations for NP_034576.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate 5' exon structure, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AL845297, L10409
      Consensus CDS
      CCDS16836.1
      UniProtKB/Swiss-Prot
      P35583
      Related
      ENSMUSP00000045918.3, OTTMUSP00000016693, ENSMUST00000047315.9, OTTMUST00000037259
      Conserved Domains (4) summary
      smart00339
      Location:159247
      FH; FORKHEAD
      pfam08430
      Location:17158
      Forkhead_N; Forkhead N-terminal region
      pfam09354
      Location:375448
      HNF_C; HNF3 C-terminal domain
      pfam16056
      Location:218313
      DUF4799; Domain of unknown function (DUF4799)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      148042877..148046969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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