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    RAD4 Rad4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856909, updated on 22-May-2018
    Gene symbol
    RAD4
    Gene description
    Rad4p
    Primary source
    SGD:S000000964
    Locus tag
    YER162C
    Gene type
    protein coding
    RNA name
    Rad4p
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See RAD4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (500630..502894, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene Spt2p Neighboring gene gamma-glutamylcyclotransferase Neighboring gene chromatin-remodeling ATPase CHD1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    damaged DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-strand break-containing DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    DNA topological change IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide-excision repair IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    XPC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide-excision repair factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleotide-excision repair factor 2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    Rad4p
    NP_011089.4
    • Protein that recognizes and binds damaged DNA (with Rad23p) during NER; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins; Rad4p-Rad23p heterodimer binds to promoters of DNA damage response genes to repress their transcription in the absence of DNA damage; NER stands for nucleotide excision repair

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      500630..502894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179052.4NP_011089.4  TPA: Rad4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011089.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P14736
      Conserved Domains (5) summary
      smart01032
      Location:551626
      BHD_3; Rad4 beta-hairpin domain 3
      smart01031
      Location:490542
      BHD_2; Rad4 beta-hairpin domain 2
      COG5535
      Location:1669
      RAD4; DNA repair protein RAD4 [DNA replication, recombination, and repair]
      pfam03835
      Location:284425
      Rad4; Rad4 transglutaminase-like domain
      pfam10403
      Location:431487
      BHD_1; Rad4 beta-hairpin domain 1
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