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    TACC3 transforming acidic coiled-coil containing protein 3 [ Homo sapiens (human) ]

    Gene ID: 10460, updated on 9-Jul-2017
    Official Symbol
    TACC3provided by HGNC
    Official Full Name
    transforming acidic coiled-coil containing protein 3provided by HGNC
    Primary source
    HGNC:HGNC:11524
    See related
    Ensembl:ENSG00000013810 MIM:605303; Vega:OTTHUMG00000089535
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERIC1; ERIC-1
    Summary
    This gene encodes a member of the transforming acidic colied-coil protein family. The encoded protein is a motor spindle protein that may play a role in stabilization of the mitotic spindle. This protein may also play a role in growth a differentiation of certain cancer cells. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    4p16.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (1721383..1745178)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (1723217..1746905)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stem-loop binding protein Neighboring gene transmembrane protein 129 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.
    NHGRI GWA Catalog
    A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.
    NHGRI GWA Catalog
    Genome-wide association study identifies multiple loci associated with bladder cancer risk.
    NHGRI GWA Catalog
    • Aurora A signaling, organism-specific biosystem (from Pathway Interaction Database)
      Aurora A signaling, organism-specific biosystem
      Aurora A signaling
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC117382, MGC133242

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    metaphase/anaphase transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization involved in mitosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    transforming acidic coiled-coil-containing protein 3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006342.2NP_006333.1  transforming acidic coiled-coil-containing protein 3

      See identical proteins and their annotated locations for NP_006333.1

      Status: REVIEWED

      Source sequence(s)
      AA682436, AC016773, AF093543, AI684124, DB098941
      Consensus CDS
      CCDS3352.1
      UniProtKB/Swiss-Prot
      Q9Y6A5
      Related
      ENSP00000326550.4, OTTHUMP00000113796, ENST00000313288.8, OTTHUMT00000203730
      Conserved Domains (2) summary
      pfam05010
      Location:639832
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:652753
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      1721383..1745178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247930.2XP_005247987.1  transforming acidic coiled-coil-containing protein 3 isoform X4

      Conserved Domains (1) summary
      pfam05010
      Location:279476
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    2. XM_005247929.2XP_005247986.1  transforming acidic coiled-coil-containing protein 3 isoform X1

      Conserved Domains (2) summary
      pfam05010
      Location:639836
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:656757
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    3. XM_011513386.2XP_011511688.1  transforming acidic coiled-coil-containing protein 3 isoform X3

      Conserved Domains (2) summary
      PRK12323
      Location:239482
      PRK12323; DNA polymerase III subunits gamma and tau; Provisional
      pfam05010
      Location:639691
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    4. XM_017007653.1XP_016863142.1  transforming acidic coiled-coil-containing protein 3 isoform X2

      UniProtKB/Swiss-Prot
      Q9Y6A5
      Conserved Domains (2) summary
      pfam05010
      Location:639832
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      cl23765
      Location:652753
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      1721189..1744883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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