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    Mmp9 matrix metallopeptidase 9 [ Mus musculus (house mouse) ]

    Gene ID: 17395, updated on 9-Jul-2017
    Official Symbol
    Mmp9provided by MGI
    Official Full Name
    matrix metallopeptidase 9provided by MGI
    Primary source
    MGI:MGI:97011
    See related
    Ensembl:ENSMUSG00000017737 Vega:OTTMUSG00000001184
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Clg4b; Gel B; MMP-9; B/MMP9; AW743869; pro-MMP-9
    Summary
    This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme that degrades collagens of type IV, V and XI, and elastin. Mice lacking the encoded protein exhibit an abnormal pattern of skeletal growth plate vascularization and ossification, reduced keratinocyte hyperproliferation at all neoplastic stages, a decreased incidence of invasive tumors, and resistance to experimental autoimmune encephalomyelitis. [provided by RefSeq, Feb 2016]
    Orthologs
    Location:
    2 H3; 2 85.27 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (164940744..164955850)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (164773751..164781346)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene PDX1 C-terminal inhibiting factor 1 Neighboring gene predicted gene, 46775 Neighboring gene zinc finger protein 335 Neighboring gene zinc finger protein 335, opposite strand Neighboring gene solute carrier family 12, member 5 Neighboring gene predicted gene, 46776 Neighboring gene nuclear receptor coactivator 5 Neighboring gene heat shock protein 90, alpha (cytosolic), class A member 1 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    collagen catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    collagen catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    embryo implantation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular matrix organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    leukocyte migration IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of fibroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    ossification IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of leukocyte migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    protein oligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tissue remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    transformation of host cell by virus ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    proteinaceous extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    matrix metalloproteinase-9
    Names
    92 kDa gelatinase
    92 kDa type IV collagenase
    92kD gelatinase
    92kD type IV collagenase
    collagenase type IVB
    gelatinase B
    NP_038627.1
    XP_006498924.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013599.4NP_038627.1  matrix metalloproteinase-9 preproprotein

      See identical proteins and their annotated locations for NP_038627.1

      Status: REVIEWED

      Source sequence(s)
      AL591495, BC046991, BX524519
      Consensus CDS
      CCDS17066.1
      UniProtKB/Swiss-Prot
      P41245
      Related
      ENSMUSP00000017881.2, OTTMUSP00000001145, ENSMUST00000017881.2, OTTMUST00000002322
      Conserved Domains (6) summary
      smart00059
      Location:223271
      FN2; Fibronectin type 2 domain
      cd00094
      Location:532729
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:115444
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:115444
      Peptidase_M10; Matrixin
      pfam01471
      Location:4195
      PG_binding_1; Putative peptidoglycan binding domain
      pfam04886
      Location:474525
      PT; PT repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      164940744..164955850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498861.2XP_006498924.1  matrix metalloproteinase-9 isoform X1

      Conserved Domains (5) summary
      smart00059
      Location:163211
      FN2; Fibronectin type 2 domain
      cd00094
      Location:472669
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:55384
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:55384
      Peptidase_M10; Matrixin
      pfam04886
      Location:414465
      PT; PT repeat
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