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    Hsf1 heat shock factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 15499, updated on 15-May-2017
    Official Symbol
    Hsf1provided by MGI
    Official Full Name
    heat shock factor 1provided by MGI
    Primary source
    MGI:MGI:96238
    See related
    Ensembl:ENSMUSG00000022556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HSTF; HSTF 1; AA960185; Hsf1beta; Hsf1alpha
    Orthologs
    Location:
    15 D3; 15 35.95 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (76477367..76500982)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (76307875..76331402)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene maestro heat-like repeat family member 1 Neighboring gene microRNA 6954 Neighboring gene block of proliferation 1 Neighboring gene scleraxis Neighboring gene diacylglycerol O-acyltransferase 1 Neighboring gene scratch family zinc finger 1

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein self-association ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific single stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor activity, sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    translation elongation factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    cellular protein complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to amino acid stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to angiotensin ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to cadmium ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to copper ion ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to diamide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to estradiol stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to hydrogen peroxide ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to organic cyclic compound ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to sodium arsenite ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    defense response ISO
    Inferred from Sequence Orthology
    more info
     
    embryonic placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic process involved in female pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    female meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cardiac muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron death ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic DNA fragmentation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA polyadenylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter in response to heat stress ISO
    Inferred from Sequence Orthology
    more info
     
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein homotrimerization ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of spindle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    response to estradiol ISO
    Inferred from Sequence Orthology
    more info
     
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to testosterone ISO
    Inferred from Sequence Orthology
    more info
     
    spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    heat shock factor protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331152.1NP_001318081.1  heat shock factor protein 1 isoform gammaalpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (gammaalpha).
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
      UniProtKB/TrEMBL
      A0A075F6C2
    2. NM_001331153.1NP_001318082.1  heat shock factor protein 1 isoform gammabeta

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform gammabeta which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      UniProtKB/TrEMBL
      A0A075F5C6
    3. NM_001331154.1NP_001318083.1  heat shock factor protein 1 isoform alpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform alpha which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398, CK622418
      UniProtKB/Swiss-Prot
      P38532
      UniProtKB/TrEMBL
      A0A075F891
    4. NM_001331214.1NP_001318143.1  heat shock factor protein 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 5, which has a shorter and distinct C-terminus, compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      UniProtKB/TrEMBL
      Q52L52
    5. NM_008296.3NP_032322.1  heat shock factor protein 1 isoform beta

      See identical proteins and their annotated locations for NP_032322.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform beta which is shorter compared to isoform gammaalpha.
      Source sequence(s)
      AC157566, AK075651, BQ445304, BU925102, CB245398
      Consensus CDS
      CCDS27572.1
      UniProtKB/Swiss-Prot
      P38532
      UniProtKB/TrEMBL
      A0A075F882
      Related
      ENSMUSP00000072617.5, ENSMUST00000072838.5
      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:258503
      Vert_HS_TF; Vertebrate heat shock transcription factor

    RNA

    1. NR_138588.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate internal exons and retains an intron in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC157566, AK075651, AK089144, BG694608, BQ445304, BU925102, CB245398
    2. NR_138589.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks multiple alternate internal exons and uses an alternate splice site in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant gammaalpha, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC157566, AK075651, AK082507, BQ445304, BU925102, CB245398, CK622418

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      76477367..76500982
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520473.3XP_006520536.1  heat shock factor protein 1 isoform X3

      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:258525
      Vert_HS_TF; Vertebrate heat shock transcription factor
    2. XM_006520471.3XP_006520534.1  heat shock factor protein 1 isoform X1

      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:258553
      Vert_HS_TF; Vertebrate heat shock transcription factor
    3. XM_006520472.3XP_006520535.1  heat shock factor protein 1 isoform X2

      Conserved Domains (2) summary
      smart00415
      Location:14118
      HSF; heat shock factor
      pfam06546
      Location:258531
      Vert_HS_TF; Vertebrate heat shock transcription factor
    4. XM_006520474.3XP_006520537.1  heat shock factor protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006520537.1

      Conserved Domains (1) summary
      pfam06546
      Location:47342
      Vert_HS_TF; Vertebrate heat shock transcription factor
    5. XM_006520476.3XP_006520539.1  heat shock factor protein 1 isoform X5

      Conserved Domains (1) summary
      pfam06546
      Location:47292
      Vert_HS_TF; Vertebrate heat shock transcription factor
    6. XM_006520475.3XP_006520538.1  heat shock factor protein 1 isoform X4

      See identical proteins and their annotated locations for XP_006520538.1

      Conserved Domains (1) summary
      pfam06546
      Location:47342
      Vert_HS_TF; Vertebrate heat shock transcription factor
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