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    Dkk1 dickkopf WNT signaling pathway inhibitor 1 [ Mus musculus (house mouse) ]

    Gene ID: 13380, updated on 5-Dec-2017
    Official Symbol
    Dkk1provided by MGI
    Official Full Name
    dickkopf WNT signaling pathway inhibitor 1provided by MGI
    Primary source
    MGI:MGI:1329040
    See related
    Ensembl:ENSMUSG00000024868 Vega:OTTMUSG00000020350
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mdkk-1
    Expression
    Biased expression in limb E14.5 (RPKM 5.1), placenta adult (RPKM 1.6) and 6 other tissues See more
    Orthologs
    Location:
    19; 19 C1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (30545876..30549496, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (30620366..30623986, complement)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 2, pseudogene 3 Neighboring gene cathepsin L pseudogene Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit E1 pseudogene Neighboring gene ubiquitin-like 5 pseudogene

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    co-receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor antagonist activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Wnt signaling pathway involved in somitogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell morphogenesis involved in differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    face morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hair follicle development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    head morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    learning or memory IDA
    Inferred from Direct Assay
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesoderm formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of age-related behavioral decline IDA
    Inferred from Direct Assay
    more info
    PubMed 
    motor learning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt-Frizzled-LRP5/6 complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of Wnt-Frizzled-LRP5/6 complex assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of mesodermal cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of pathway-restricted SMAD protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of skeletal muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of midbrain dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of tau-protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of endodermal cell fate specification ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synapse organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic transmission, glutamatergic IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to retinoic acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    dickkopf-related protein 1
    Names
    dickkopf homolog 1
    dickkopf-1
    dickkopf-like protein 1
    dkk-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010051.3NP_034181.2  dickkopf-related protein 1 precursor

      See identical proteins and their annotated locations for NP_034181.2

      Status: PROVISIONAL

      Source sequence(s)
      AC103405
      Consensus CDS
      CCDS29744.1
      UniProtKB/Swiss-Prot
      O54908
      Related
      ENSMUSP00000025803.8, OTTMUSP00000022079, ENSMUST00000025803.8, OTTMUST00000048273
      Conserved Domains (1) summary
      pfam04706
      Location:86142
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      30545876..30549496 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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