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    KRIT1 KRIT1, ankyrin repeat containing [ Homo sapiens (human) ]

    Gene ID: 889, updated on 5-Nov-2017
    Official Symbol
    KRIT1provided by HGNC
    Official Full Name
    KRIT1, ankyrin repeat containingprovided by HGNC
    Primary source
    HGNC:HGNC:1573
    See related
    Ensembl:ENSG00000001631 MIM:604214; Vega:OTTHUMG00000131187
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAM; CCM1
    Summary
    This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 10.0) and 25 other tissues See more
    Orthologs
    Location:
    7q21.2
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (92198969..92246128, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (91828283..91875414, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 51 subfamily A member 1 Neighboring gene CYP51A1 antisense RNA 1 Neighboring gene leucine rich repeats and death domain containing 1 Neighboring gene microRNA 1285-1 Neighboring gene ankyrin repeat and IBR domain containing 1 Neighboring gene transmembrane BAX inhibitor motif containing 7, pseudogene

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
      Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    • Rap1 signaling pathway, conserved biosystem (from KEGG)
      Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    GTPase regulator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidylinositol-4,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of establishment of cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    krev interaction trapped protein 1
    Names
    ankyrin repeat-containing protein Krit1
    cerebral cavernous malformations 1 protein
    krev interaction trapped 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012964.1 RefSeqGene

      Range
      5001..52132
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_650

    mRNA and Protein(s)

    1. NM_001013406.2NP_001013424.1  krev interaction trapped protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001013424.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has an alternate 5' exon, and lacks 2 exons in the 5' UTR and an in-frame exon in the coding region, as compared to variant 1. The encoded isoform 2 lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AC000120
      Consensus CDS
      CCDS34679.1
      UniProtKB/Swiss-Prot
      O00522
      Related
      ENSP00000378011.2, OTTHUMP00000208802, ENST00000394503.6
      Conserved Domains (5) summary
      smart00295
      Location:373592
      B41; Band 4.1 homologues
      cd13197
      Location:588687
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:306338
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:282363
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    2. NM_001350669.1NP_001337598.1  krev interaction trapped protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 5 and 7, encodes isoform 2.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:373592
      B41; Band 4.1 homologues
      cd13197
      Location:588687
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:306338
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:282363
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    3. NM_001350670.1NP_001337599.1  krev interaction trapped protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 5 and 6, encodes isoform 2.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:373592
      B41; Band 4.1 homologues
      cd13197
      Location:588687
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:306338
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:282363
      Ank_2; Ankyrin repeats (3 copies)
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    4. NM_001350671.1NP_001337600.1  krev interaction trapped protein 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC000120
      Conserved Domains (4) summary
      smart00295
      Location:183402
      B41; Band 4.1 homologues
      cd00204
      Location:53173
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:398497
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:5380
      ANK; ANK repeat [structural motif]
    5. NM_001350672.1NP_001337601.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1-4 and 10-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    6. NM_001350673.1NP_001337602.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1-4, 9, and 11-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    7. NM_001350674.1NP_001337603.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1-4, 9, 10, and 12-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    8. NM_001350675.1NP_001337604.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1-4, 9-11, and 13-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    9. NM_001350676.1NP_001337605.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1-4, 9-12, and 14-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    10. NM_001350677.1NP_001337606.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1-4, 9-13, and 15-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    11. NM_001350678.1NP_001337607.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1-4, 9-14, and 16-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    12. NM_001350679.1NP_001337608.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1-4, 9-15, and 17-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    13. NM_001350680.1NP_001337609.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variants 1-4 and 9-33, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    14. NM_001350681.1NP_001337610.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1-4, 9-16, and 18-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    15. NM_001350682.1NP_001337611.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 1-4, 9-17, and 19-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    16. NM_001350683.1NP_001337612.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 1-4, 9-18, and 20-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    17. NM_001350684.1NP_001337613.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 1-4, 9-19, and 21-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    18. NM_001350685.1NP_001337614.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 1-4, 9-20, and 22-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    19. NM_001350686.1NP_001337615.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 1-4, 9-21, and 23-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    20. NM_001350687.1NP_001337616.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 1-4, 9-22, and 24-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    21. NM_001350688.1NP_001337617.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 1-4, 9-23, and 25-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    22. NM_001350689.1NP_001337618.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 1-4, 9-24, and 26-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    23. NM_001350690.1NP_001337619.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variants 1-4, 9-25, and 27-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    24. NM_001350691.1NP_001337620.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (27), as well as variants 1-4, 9-26, and 28-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    25. NM_001350692.1NP_001337621.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (28), as well as variants 1-4, 9-27, and 29-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    26. NM_001350693.1NP_001337622.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 1-4, 9-28, and 30-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    27. NM_001350694.1NP_001337623.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 1-4, 9-29, and 31-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    28. NM_001350695.1NP_001337624.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 1-4, 9-30, and 32-34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    29. NM_001350696.1NP_001337625.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 1-4, 9-31, 33, and 34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    30. NM_001350697.1NP_001337626.1  krev interaction trapped protein 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 1-4, 9-32, and 34, encodes isoform 1.
      Source sequence(s)
      AC000120
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    31. NM_004912.4NP_004903.2  krev interaction trapped protein 1 isoform 1

      See identical proteins and their annotated locations for NP_004903.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the 5' exon but has an alternate segment in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC000120
      Consensus CDS
      CCDS5624.1
      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Related
      ENSP00000410909.2, OTTHUMP00000208804, ENST00000412043.6
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    32. NM_194454.2NP_919436.1  krev interaction trapped protein 1 isoform 1

      See identical proteins and their annotated locations for NP_919436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks 2 exons but has an alternate exon in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AC000120
      Consensus CDS
      CCDS5624.1
      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Related
      ENSP00000378013.2, OTTHUMP00000208803, ENST00000394505.6
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    33. NM_194455.1NP_919437.1  krev interaction trapped protein 1 isoform 1

      See identical proteins and their annotated locations for NP_919437.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has 2 alternate exons in the 5' UTR, as compared to variant 1. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AF388384
      Consensus CDS
      CCDS5624.1
      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Related
      ENSP00000344668.2, OTTHUMP00000161833, ENST00000340022.6, OTTHUMT00000253910
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    34. NM_194456.1NP_919438.1  krev interaction trapped protein 1 isoform 1

      See identical proteins and their annotated locations for NP_919438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) includes 4 exons in the 5' UTR. Variants 1-4 encode the same isoform (1).
      Source sequence(s)
      AF296765, AF388384, AJ294850
      Consensus CDS
      CCDS5624.1
      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Related
      ENSP00000378015.1, ENST00000394507.5
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      92198969..92246128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017012755.1XP_016868244.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    2. XM_011516653.2XP_011514955.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    3. XM_005250667.2XP_005250724.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    4. XM_006716161.3XP_006716224.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    5. XM_011516661.2XP_011514963.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    6. XM_006716163.3XP_006716226.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    7. XM_005250665.3XP_005250722.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    8. XM_005250666.3XP_005250723.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_005250723.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    9. XM_017012756.1XP_016868245.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    10. XM_011516657.2XP_011514959.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    11. XM_006716162.3XP_006716225.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006716225.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    12. XM_005250668.3XP_005250725.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    13. XM_005250660.3XP_005250717.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    14. XM_011516655.2XP_011514957.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514957.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    15. XM_005250669.3XP_005250726.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    16. XM_005250662.3XP_005250719.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    17. XM_011516659.2XP_011514961.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514961.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    18. XM_011516654.2XP_011514956.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514956.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    19. XM_017012757.1XP_016868246.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    20. XM_011516651.2XP_011514953.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514953.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    21. XM_017012759.1XP_016868248.1  krev interaction trapped protein 1 isoform X2

      Conserved Domains (4) summary
      smart00295
      Location:183402
      B41; Band 4.1 homologues
      cd00204
      Location:53173
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:398497
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:5380
      ANK; ANK repeat [structural motif]
    22. XM_017012758.1XP_016868247.1  krev interaction trapped protein 1 isoform X2

      Conserved Domains (4) summary
      smart00295
      Location:183402
      B41; Band 4.1 homologues
      cd00204
      Location:53173
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:398497
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:5380
      ANK; ANK repeat [structural motif]
    23. XM_011516656.2XP_011514958.1  krev interaction trapped protein 1 isoform X1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    24. XM_011516660.2XP_011514962.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514962.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT
    25. XM_011516658.2XP_011514960.1  krev interaction trapped protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011514960.1

      UniProtKB/Swiss-Prot
      O00522
      UniProtKB/TrEMBL
      A4D1F7
      Conserved Domains (5) summary
      smart00295
      Location:421640
      B41; Band 4.1 homologues
      cd00204
      Location:291411
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd13197
      Location:636735
      FERM_C_CCM1; FERM domain C-lobe of Cerebral cavernous malformation 1
      sd00045
      Location:291318
      ANK; ANK repeat [structural motif]
      pfam16705
      Location:30198
      NUDIX_5; NUDIX, or N-terminal NPxY motif-rich, region of KRIT

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      91758320..91805450 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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