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    SCH9 serine/threonine protein kinase SCH9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856612, updated on 13-Jan-2018
    Gene symbol
    SCH9
    Gene description
    serine/threonine protein kinase SCH9
    Primary source
    SGD:S000001248
    Locus tag
    YHR205W
    Gene type
    protein coding
    RNA name
    serine/threonine protein kinase SCH9
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HRM2; KOM1
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (509363..511837)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S4B Neighboring gene alpha-1,2-mannosidase MNL1 Neighboring gene kinase-regulated stress-responsive transcription factor SKN7 Neighboring gene S-adenosylmethionine-dependent methyltransferase

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    age-dependent response to oxidative stress involved in chronological cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase I promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase I promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase III promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase III promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of sphingolipid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    replicative cell aging IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    colocalizes_with chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Names
    serine/threonine protein kinase SCH9
    NP_012075.1
    • AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      509363..511837
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179336.1NP_012075.1  TPA: serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11792
      Conserved Domains (3) summary
      cd11651
      Location:181407
      YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
      smart00220
      Location:412671
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd05586
      Location:418738
      STKc_Sck1_like; Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases
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