Camk1g calcium/calmodulin-dependent protein kinase I gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camk1gprovided by MGI
Official Full Name: calcium/calmodulin-dependent protein kinase I gammaprovided by MGI
Primary source: MGI:MGI:2388073
See related: Ensembl:ENSMUSG00000016179 AllianceGenome:MGI:2388073
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CLICK III; CLICK-III; CaMKIgamma
Summary: Enables calmodulin-dependent protein kinase activity. Predicted to be involved in peptidyl-serine phosphorylation. Predicted to act upstream of or within phosphorylation. Located in endomembrane system and plasma membrane. Part of calcium- and calmodulin-dependent protein kinase complex. Is expressed in several structures, including genitourinary system; heart; nervous system; and retina. Orthologous to human CAMK1G (calcium/calmodulin dependent protein kinase IG). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in CNS E18 (RPKM 15.3), whole brain E14.5 (RPKM 12.6) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.74 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (193028654..193052636, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (193346346..193370355, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons
Title: Calmodulin suppresses synaptotagmin-2 transcription in cortical neurons.
CLICK-III/CaMKIgamma is a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
Title: Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK).
CL3 may represent a key element in the Ca(2+)-dependent and lipid-raft-delineated switch that turns on extrinsic activity-regulated dendrite formation in developing cortical neurons.
Title: Regulation of dendritogenesis via a lipid-raft-associated Ca2+/calmodulin-dependent protein kinase CLICK-III/CaMKIgamma.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Camk1g (e-PCR), detects polymorphism
- UniSTS:525969

Camk1g (e-PCR), detects polymorphism
- UniSTS:525970

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
part_of calcium- and calmodulin-dependent protein kinase complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular anatomical structure	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase type 1G

Names: caM kinase I gamma; caM kinase IG; caM-KI gamma; caMK-like CREB kinase III; caMKI gamma; caMKIG

NP_001408321.1

EC 2.7.11.17

NP_001408322.1

EC 2.7.11.17

NP_659066.1

EC 2.7.11.17

XP_030108815.1

EC 2.7.11.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421392.1 → NP_001408321.1 calcium/calmodulin-dependent protein kinase type 1G isoform 1

Status: VALIDATED

Source sequence(s)

AC022675
NM_001421393.1 → NP_001408322.1 calcium/calmodulin-dependent protein kinase type 1G isoform 3

Status: VALIDATED

Source sequence(s)

AC022675
NM_144817.3 → NP_659066.1 calcium/calmodulin-dependent protein kinase type 1G isoform 2

See identical proteins and their annotated locations for NP_659066.1

Status: VALIDATED

Source sequence(s)

AC022675

Consensus CDS

CCDS15638.1

UniProtKB/Swiss-Prot

Q91VB2

Related

ENSMUSP00000016323.5, ENSMUST00000016323.11

Conserved Domains (2) summary

smart00220
Location:23 → 277

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14166
Location:19 → 303

STKc_CaMKI_gamma; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

193028654..193052636 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252955.2 → XP_030108815.1 calcium/calmodulin-dependent protein kinase type 1G isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 207

PKc_like; Protein Kinases, catalytic domain