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    RSP5 NEDD4 family E3 ubiquitin-protein ligase [ Saccharomyces cerevisiae S288c ]

    Gene ID: 856862, updated on 9-Apr-2017
    Gene symbol
    RSP5
    Gene description
    NEDD4 family E3 ubiquitin-protein ligase
    Primary source
    SGD:S000000927
    Locus tag
    YER125W
    Gene type
    protein coding
    RNA name
    NEDD4 family E3 ubiquitin-protein ligase
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    MDP1; MUT2; NPI1; SMM1; UBY1
    See RSP5 in Map Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (410189..412618)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene casein kinase YCK3 Neighboring gene Dse1p Neighboring gene rRNA-processing protein NSA2 Neighboring gene Lcp5p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Function Evidence Code Pubs
    phosphatidylinositol binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin assembly or disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    late endosome to vacuole transport via multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    late endosome to vacuole transport via multivesicular body sorting pathway IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein autoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein monoubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein monoubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of dolichol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of dolichol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ergosterol biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of initiation of mating projection growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mRNA export from nucleus IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of multivesicular body size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of nitrogen utilization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of phosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    regulation of rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of ubiquinone biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to drug IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ribophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ubiquitin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
     
    cellular bud tip IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Names
    NEDD4 family E3 ubiquitin-protein ligase
    NP_011051.3
    • NEDD4 family E3 ubiquitin ligase; regulates processes including: MVB sorting, the heat shock response, transcription, endocytosis and ribosome stability; ubiquitinates Sec23p, Sna3p, Ste4p, Nfi1p, Rpo21p and Sem1p; autoubiquitinates; deubiquitinated by Ubp2p; regulated by SUMO ligase Siz1p, in turn regulates Siz1p SUMO ligase activity; required for efficient Golgi-to-ER trafficking in COPI mutants; mutant tolerates aneuploidy; human homolog implicated in Liddle syndrome

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      410189..412618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179015.3NP_011051.3  TPA: NEDD4 family E3 ubiquitin-protein ligase [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_011051.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P39940
      Conserved Domains (5) summary
      smart00456
      Location:388420
      WW; Domain with 2 conserved Trp (W) residues
      COG5021
      Location:3809
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00078
      Location:455807
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00397
      Location:231260
      WW; WW domain
      cl14603
      Location:4136
      C2; C2 domain
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