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    Slc12a2 solute carrier family 12 member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83629, updated on 12-Nov-2017
    Official Symbol
    Slc12a2provided by RGD
    Official Full Name
    solute carrier family 12 member 2provided by RGD
    Primary source
    RGD:620809
    See related
    Ensembl:ENSRNOG00000015971
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Bsc2; Nkcc1
    Summary
    Na/K/2Cl cotransporter involved in maintainence of intracellular Cl(-) levels [RGD, Feb 2006]
    Expression
    Biased expression in Brain (RPKM 351.2), Muscle (RPKM 334.0) and 9 other tissues See more
    Orthologs
    Location:
    18q12.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (52917124..52985281)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (52104434..52172638)

    Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene similar to ribosomal protein L10 Neighboring gene uncharacterized LOC102548156 Neighboring gene fibrillin 2 Neighboring gene uncharacterized LOC102548224

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    ammonium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    ammonium transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cation:chloride symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    sodium:potassium:chloride symporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    ammonium transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    branching involved in mammary gland duct morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    chloride transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    gamma-aminobutyric acid signaling pathway IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    hyperosmotic response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary duct terminal end bud growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of cell volume IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transepithelial ammonium transport IEA
    Inferred from Electronic Annotation
    more info
     
    transepithelial ammonium transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    transepithelial chloride transport IEA
    Inferred from Electronic Annotation
    more info
     
    transepithelial chloride transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    extracellular vesicle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    solute carrier family 12 member 2
    Names
    solute carrier family 12 (sodium/potassium/chloride transporter), member 2
    solute carrier family 12 (sodium/potassium/chloride transporters), member 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031798.1NP_113986.1  solute carrier family 12 member 2

      See identical proteins and their annotated locations for NP_113986.1

      Status: PROVISIONAL

      Source sequence(s)
      AF051561
      UniProtKB/TrEMBL
      Q9QX10
      Related
      ENSRNOP00000021921.4, ENSRNOT00000021921.4
      Conserved Domains (4) summary
      TIGR00930
      Location:2071203
      2a30; K-Cl cotransporter
      pfam03522
      Location:7921203
      SLC12; Solute carrier family 12
      pfam08403
      Location:193254
      AA_permease_N; Amino acid permease N-terminal
      pfam15772
      Location:368
      UPF0688; UPF0688 family

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

      Range
      52917124..52985281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006254752.3XP_006254814.1  solute carrier family 12 member 2 isoform X1

      Conserved Domains (4) summary
      TIGR00930
      Location:2071187
      2a30; K-Cl cotransporter
      pfam03522
      Location:7921187
      SLC12; Solute carrier family 12
      pfam08403
      Location:193254
      AA_permease_N; Amino acid permease N-terminal
      pfam15772
      Location:368
      UPF0688; UPF0688 family

    Alternate Rn_Celera

    Genomic

    1. AC_000086.1 Alternate Rn_Celera

      Range
      49478614..49546320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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