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    Casp14 caspase 14 [ Mus musculus (house mouse) ]

    Gene ID: 12365, updated on 25-May-2017
    Official Symbol
    Casp14provided by MGI
    Official Full Name
    caspase 14provided by MGI
    Primary source
    MGI:MGI:1335092
    See related
    Ensembl:ENSMUSG00000005355
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MICE; mini-ICE
    Orthologs
    Location:
    10; 10 C1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (78711995..78718347, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (78174740..78181038, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1357 Neighboring gene L-2-hydroxyglutarate dehydrogenase pseudogene Neighboring gene coiled-coil domain containing 105 Neighboring gene predicted gene, 30400 Neighboring gene predicted gene, 40710 Neighboring gene solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Clone Names

    • MGC123948, MGC123949

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    cornification IEA
    Inferred from Electronic Annotation
    more info
     
    execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    proteolysis RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    keratin filament ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    caspase-14
    Names
    CASP-14
    NP_033939.1
    XP_006513223.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009809.5NP_033939.1  caspase-14

      See identical proteins and their annotated locations for NP_033939.1

      Status: VALIDATED

      Source sequence(s)
      AJ007750, AK081645, BY134001
      Consensus CDS
      CCDS23969.1
      UniProtKB/Swiss-Prot
      O89094
      UniProtKB/TrEMBL
      Q542Q1
      Related
      ENSMUSP00000005488.7, ENSMUST00000005488.8
      Conserved Domains (1) summary
      cd00032
      Location:10257
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      78711995..78718347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513160.3XP_006513223.1  caspase-14 isoform X1

      UniProtKB/Swiss-Prot
      O89094
      Conserved Domains (1) summary
      cl00042
      Location:10140
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
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