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    CHGA chromogranin A [ Homo sapiens (human) ]

    Gene ID: 1113, updated on 8-Oct-2017
    Official Symbol
    CHGAprovided by HGNC
    Official Full Name
    chromogranin Aprovided by HGNC
    Primary source
    HGNC:HGNC:1929
    See related
    Ensembl:ENSG00000100604 MIM:118910; Vega:OTTHUMG00000171225
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CGA
    Summary
    The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
    Orthologs
    Location:
    14q32.12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 14 NC_000014.9 (92922589..92935293)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93389445..93401638)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370629 Neighboring gene long intergenic non-protein coding RNA 2287 Neighboring gene inositol-tetrakisphosphate 1-kinase Neighboring gene ITPK1 antisense RNA 1 Neighboring gene cytochrome b5 type A pseudogene 3

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
      Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    adrenergic receptor signaling pathway involved in cardiac muscle relaxation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    antimicrobial humoral response TAS
    Traceable Author Statement
    more info
     
    defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    defense response to fungus IEA
    Inferred from Electronic Annotation
    more info
     
    innate immune response NAS
    Non-traceable Author Statement
    more info
    PubMed 
    killing of cells of other organism IEA
    Inferred from Electronic Annotation
    more info
     
    mast cell activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mast cell degranulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of blood vessel diameter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of catecholamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    organelle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cAMP metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of cardiac muscle contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of dense core granule biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of blood pressure TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of the force of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    chromaffin granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mast cell granule IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    secretory granule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    chromogranin-A
    Names
    SP-I
    betagranin (N-terminal fragment of chromogranin A)
    catestatin
    chromofungin
    parathyroid secretory protein 1
    pituitary secretory protein I

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001275.3NP_001266.1  chromogranin-A isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_001266.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC001059, BC009384, BX248263, DA201149
      Consensus CDS
      CCDS9906.1
      UniProtKB/Swiss-Prot
      P10645
      UniProtKB/TrEMBL
      Q86T07
      Related
      ENSP00000216492.5, OTTHUMP00000245492, ENST00000216492.9, OTTHUMT00000412411
      Conserved Domains (1) summary
      pfam01271
      Location:25457
      Granin; Granin (chromogranin or secretogranin)
    2. NM_001301690.1NP_001288619.1  chromogranin-A isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_001288619.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BC009384, BX248263, DA201149
      Consensus CDS
      CCDS76718.1
      UniProtKB/Swiss-Prot
      P10645
      UniProtKB/TrEMBL
      G5E968, Q86T07
      Related
      ENSP00000334023.4, OTTHUMP00000245495, ENST00000334654.4, OTTHUMT00000412414
      Conserved Domains (1) summary
      pfam01271
      Location:116306
      Granin; Granin (chromogranin or secretogranin)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p7 Primary Assembly

      Range
      92922589..92935293
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536370.1XP_011534672.1  chromogranin-A isoform X1

      See identical proteins and their annotated locations for XP_011534672.1

      UniProtKB/Swiss-Prot
      P10645
      Conserved Domains (1) summary
      pfam01271
      Location:25457
      Granin; Granin (chromogranin or secretogranin)

    Reference GRCh38.p7 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p7 ALT_REF_LOCI_1

      Range
      37662..49855
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018925.2 Alternate CHM1_1.1

      Range
      93327694..93339887
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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