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    Lrp1 low density lipoprotein receptor-related protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 16971, updated on 23-Apr-2017
    Official Symbol
    Lrp1provided by MGI
    Official Full Name
    low density lipoprotein receptor-related protein 1provided by MGI
    Primary source
    MGI:MGI:96828
    See related
    Ensembl:ENSMUSG00000040249 Vega:OTTMUSG00000031813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrp; A2mr; CD91; AI316852; b2b1554Clo
    Orthologs
    Location:
    10; 10 D3
    Exon count:
    89
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (127538157..127621148, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (126975213..127058204, complement)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial) Neighboring gene neurexophilin 4 Neighboring gene predicted gene, 40802 Neighboring gene uncharacterized LOC105245328 Neighboring gene signal transducer and activator of transcription 6

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (10)  1 citation
    • Chemically induced (ENU) (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    alpha-2 macroglobulin receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    apolipoprotein binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    aorta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic cell clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    beta-amyloid clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cardiac septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cholesterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    coronary vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of smooth muscle cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of lipid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    receptor-mediated endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cholesterol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of phospholipase A2 activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    clathrin-coated pit IEA
    Inferred from Electronic Annotation
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    prolow-density lipoprotein receptor-related protein 1
    Names
    LRP-1
    alpha 2-macroglobulin receptor
    lipoprotein receptor-related protein
    lrp1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008512.2NP_032538.2  prolow-density lipoprotein receptor-related protein 1 precursor

      See identical proteins and their annotated locations for NP_032538.2

      Status: VALIDATED

      Source sequence(s)
      AC167719, AF367720, AK078273, AK154429, BU615020, CA888999, CB527265, CF535491, X67469
      Consensus CDS
      CCDS24245.1
      UniProtKB/Swiss-Prot
      Q91ZX7
      UniProtKB/TrEMBL
      A0A0R4J0I9, Q3U454
      Related
      ENSMUSP00000044004.8, OTTMUSP00000041991, ENSMUST00000049149.14, OTTMUST00000078868
      Conserved Domains (8) summary
      smart00192
      Location:34943527
      LDLa; Low-density lipoprotein receptor domain class A
      smart00135
      Location:30953137
      LY; Low-density lipoprotein-receptor YWTD domain
      smart00179
      Location:29833012
      EGF_CA; Calcium-binding EGF-like domain
      COG3386
      Location:22542464
      YvrE; Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]
      cd00112
      Location:35763610
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam00058
      Location:40144054
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam12662
      Location:29632986
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:808843
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      127538157..127621148 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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