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    Slc2a4 solute carrier family 2 (facilitated glucose transporter), member 4 [ Mus musculus (house mouse) ]

    Gene ID: 20528, updated on 19-Sep-2017
    Official Symbol
    Slc2a4provided by MGI
    Official Full Name
    solute carrier family 2 (facilitated glucose transporter), member 4provided by MGI
    Primary source
    MGI:MGI:95758
    See related
    Ensembl:ENSMUSG00000018566 Vega:OTTMUSG00000006028
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    twgy; Glut4; Glut-4
    Orthologs
    Location:
    11 B3; 11 42.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69942286..69948217, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69755788..69761692, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene Y box protein 2 Neighboring gene cofilin 1, non-muscle pseudogene Neighboring gene claudin 7

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (3)  1 citation
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    D-glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    glucose transmembrane transporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    insulin-responsive hydrogen:glucose symporter activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    substrate-specific transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    amylopectin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to tumor necrosis factor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    glucose import in response to insulin stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transport ISO
    Inferred from Sequence Orthology
    more info
     
    glucose transport TAS
    Traceable Author Statement
    more info
    PubMed 
    transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated pit ISO
    Inferred from Sequence Orthology
    more info
     
    clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endomembrane system IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endosome ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-responsive compartment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    insulin-responsive compartment ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    multivesicular body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    solute carrier family 2, facilitated glucose transporter member 4
    Names
    GT2
    glucose transporter type 4, insulin-responsive

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009204.2NP_033230.2  solute carrier family 2, facilitated glucose transporter member 4

      See identical proteins and their annotated locations for NP_033230.2

      Status: VALIDATED

      Source sequence(s)
      AK137607, AL596185
      Consensus CDS
      CCDS36201.1
      UniProtKB/Swiss-Prot
      P14142
      Related
      ENSMUSP00000018710.6, OTTMUSP00000006275, ENSMUST00000018710.12, OTTMUST00000013537
      Conserved Domains (2) summary
      cd06174
      Location:78447
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:27483
      Sugar_tr; Sugar (and other) transporter

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69942286..69948217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532653.2XP_006532716.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

      See identical proteins and their annotated locations for XP_006532716.1

      Conserved Domains (2) summary
      cd06174
      Location:1355
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:1391
      Sugar_tr; Sugar (and other) transporter
    2. XM_006532655.3XP_006532718.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X2

      See identical proteins and their annotated locations for XP_006532718.1

      Conserved Domains (2) summary
      cd06174
      Location:130290
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:1326
      Sugar_tr; Sugar (and other) transporter
    3. XM_006532654.1XP_006532717.1  solute carrier family 2, facilitated glucose transporter member 4 isoform X1

      See identical proteins and their annotated locations for XP_006532717.1

      Conserved Domains (2) summary
      cd06174
      Location:1355
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam00083
      Location:1391
      Sugar_tr; Sugar (and other) transporter

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187026.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      46816..52720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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