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    Lats2 large tumor suppressor 2 [ Mus musculus (house mouse) ]

    Gene ID: 50523, updated on 13-Jun-2017
    Official Symbol
    Lats2provided by MGI
    Official Full Name
    large tumor suppressor 2provided by MGI
    Primary source
    MGI:MGI:1354386
    See related
    Ensembl:ENSMUSG00000021959 Vega:OTTMUSG00000037614
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV277261; AW228608; 4932411G09Rik
    Orthologs
    Location:
    14; 14 C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (57689662..57746123, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (58308499..58364960, complement)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene EEF1A alpha lysine methyltransferase 1 Neighboring gene RIKEN cDNA 1700039M10 gene Neighboring gene exportin 4 Neighboring gene microRNA 3077 Neighboring gene Sin3-associated polypeptide 18 Neighboring gene spindle and kinetochore associated complex subunit 3 Neighboring gene mitochondrial ribosomal protein L57

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular protein localization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippo signaling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hippo signaling ISO
    Inferred from Sequence Orthology
    more info
     
    hormone-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    inner cell mass cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner cell mass cellular morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    keratinocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cyclin-dependent protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    serine/threonine-protein kinase LATS2
    Names
    kinase phosphorylated during mitosis protein
    large tumor suppressor homolog 2
    lats2
    serine/threonine-protein kinase kpm
    NP_056586.2
    NP_700431.1
    XP_006519287.1
    XP_006519288.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015771.2NP_056586.2  serine/threonine-protein kinase LATS2 isoform 1

      See identical proteins and their annotated locations for NP_056586.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      BC053028, BU705730
      Consensus CDS
      CCDS27158.1
      UniProtKB/Swiss-Prot
      Q7TSJ6
      Related
      ENSMUSP00000022531.7, OTTMUSP00000054318, ENSMUST00000022531.13, OTTMUST00000097026
      Conserved Domains (3) summary
      smart00220
      Location:626931
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:100140
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
      cl21453
      Location:6241004
      PKc_like; Protein Kinases, catalytic domain
    2. NM_153382.1NP_700431.1  serine/threonine-protein kinase LATS2 isoform 2

      See identical proteins and their annotated locations for NP_700431.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) lacks the first exon, most of the 3' coding region and uses a different terminal exon compared to variant A. The resulting protein (isoform 2, also called LATS2B) is much shorter and has a distinct C-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC154504, BF147719
      Consensus CDS
      CCDS49508.1
      UniProtKB/TrEMBL
      Q8VHE2
      Related
      ENSMUSP00000077130.6, OTTMUSP00000054324, ENSMUST00000077981.6, OTTMUST00000097032

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      57689662..57746123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519224.3XP_006519287.1  serine/threonine-protein kinase LATS2 isoform X1

      Related
      ENSMUSP00000133976.1, OTTMUSP00000054320, ENSMUST00000173990.7, OTTMUST00000097028
      Conserved Domains (3) summary
      smart00220
      Location:626847
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14398
      Location:100140
      UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2
      cl21453
      Location:624847
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006519225.2XP_006519288.1  serine/threonine-protein kinase LATS2 isoform X2

      See identical proteins and their annotated locations for XP_006519288.1

      UniProtKB/TrEMBL
      Q8VHE2
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