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    RCC1 regulator of chromosome condensation 1 [ Homo sapiens (human) ]

    Gene ID: 1104, updated on 5-Nov-2017
    Official Symbol
    RCC1provided by HGNC
    Official Full Name
    regulator of chromosome condensation 1provided by HGNC
    Primary source
    HGNC:HGNC:1913
    See related
    Ensembl:ENSG00000180198 MIM:179710; Vega:OTTHUMG00000003645
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHC1; RCC1-I; SNHG3-RCC1
    Expression
    Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues See more
    Orthologs
    Location:
    1p35.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 1 NC_000001.11 (28505943..28539196)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28832455..28865708)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 18 Neighboring gene phosphatase and actin regulator 4 Neighboring gene RNA, U6atac small nuclear 27, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 73A Neighboring gene small nucleolar RNA, H/ACA box 73B Neighboring gene small nucleolar RNA host gene 3 Neighboring gene peroxiredoxin 3 pseudogene 2 Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene small nucleolar RNA, C/D box 99 Neighboring gene small nucleolar RNA host gene 12

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human regulator of chromosome condensation 1 (RCC1) at amino acid residues 38-39 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
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      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Infectious disease, organism-specific biosystem (from REACTOME)
      Infectious disease, organism-specific biosystem
      Infectious disease
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
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    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • Rev-mediated nuclear export of HIV RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Readthrough RCC1

    Included gene: SNHG3

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Ran GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ran guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Ran guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Ran guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of molecular function IEA
    Inferred from Electronic Annotation
    more info
     
    spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    regulator of chromosome condensation
    Names
    SNHG3-RCC1 readthrough
    cell cycle regulatory protein
    guanine nucleotide-releasing protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048194.2NP_001041659.1  regulator of chromosome condensation isoform a

      See identical proteins and their annotated locations for NP_001041659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC069198, BF590413, X12654
      Consensus CDS
      CCDS41295.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      A0A0S2Z404
      Related
      ENSP00000362937.3, OTTHUMP00000211005, ENST00000373831.7, OTTHUMT00000010324
      Conserved Domains (1) summary
      pfam00415
      Location:394445
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. NM_001048195.2NP_001041660.1  regulator of chromosome condensation isoform b

      See identical proteins and their annotated locations for NP_001041660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      BF590413, BM546148, BQ436549, X12654
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      A0A0S2Z3I4
      Related
      ENSP00000413644.1, OTTHUMP00000211007, ENST00000411533.5, OTTHUMT00000010326
      Conserved Domains (2) summary
      COG5184
      Location:21435
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:380431
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    3. NM_001048199.2NP_001041664.1  regulator of chromosome condensation isoform c

      See identical proteins and their annotated locations for NP_001041664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 3 and 4 encode the same isoform. This variant is a read-through transcript between the upstream non-coding SNHG3 locus (GeneID:8420) and the downstream RCC1 locus (GeneID:1104).
      Source sequence(s)
      BC007300, BF590413, BF667678, BU501614
      Consensus CDS
      CCDS323.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      Q5T081
      Related
      ENSP00000381931.2, ENST00000398958.6
      Conserved Domains (1) summary
      cl27697
      Location:4418
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    4. NM_001269.4NP_001260.1  regulator of chromosome condensation isoform c

      See identical proteins and their annotated locations for NP_001260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      BF590413, X12654
      Consensus CDS
      CCDS323.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      Q5T081
      Related
      ENSP00000362938.1, OTTHUMP00000003775, ENST00000373832.5, OTTHUMT00000010321
      Conserved Domains (1) summary
      cl27697
      Location:4418
      RCC1; Regulator of chromosome condensation (RCC1) repeat

    RNA

    1. NR_030725.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) includes alternate 5' exon structure, compared to variant 1. This variant is a read-through transcript between the upstream non-coding SNHG3 locus (GeneID:8420) and the downstream RCC1 locus (GeneID:1104). This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the longest ORF, as found in variant 1. Translation of the upstream ORF would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BF590413, BF667678, BU622451, BX109495, CB985055, X06130
    2. NR_030726.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) includes alternate 5' exon structure, compared to variant 1. This variant is a read-through transcript between the upstream non-coding SNHG3 locus (GeneID:8420) and the downstream RCC1 locus (GeneID:1104). This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to inhibit the translation of the longest ORF, as found in variant 1. Translation of the upstream ORF would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC007300, BC036903, BF590413, BF667678, CB985055

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p7 Primary Assembly

      Range
      28505943..28539196
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018912.2 Alternate CHM1_1.1

      Range
      28947946..28981201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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