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    CTDNEP1 CTD nuclear envelope phosphatase 1 [ Homo sapiens (human) ]

    Gene ID: 23399, updated on 27-Mar-2017
    Official Symbol
    CTDNEP1provided by HGNC
    Official Full Name
    CTD nuclear envelope phosphatase 1provided by HGNC
    Primary source
    HGNC:HGNC:19085
    See related
    Ensembl:ENSG00000175826 MIM:610684; Vega:OTTHUMG00000102180
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET56; DULLARD; HSA011916
    Orthologs
    Location:
    17p13.1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 17 NC_000017.11 (7243587..7251940, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (7146906..7155259, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene PHD finger protein 23 Neighboring gene GABA type A receptor-associated protein Neighboring gene elongator acetyltransferase complex subunit 5 Neighboring gene claudin 7 Neighboring gene solute carrier family 2 member 4

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Depolymerisation of the Nuclear Lamina, organism-specific biosystem (from REACTOME)
      Depolymerisation of the Nuclear Lamina, organism-specific biosystemThe nuclear envelope breakdown in mitotic prophase involves depolymerisation of lamin filaments, the main constituents of the nuclear lamina. The nuclear lamina is located at the nuclear face of the ...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Mitotic Prophase, organism-specific biosystem (from REACTOME)
      Mitotic Prophase, organism-specific biosystemDuring prophase, the chromatin in the nucleus condenses, and the nucleolus disappears. Centrioles begin moving to the opposite poles or sides of the cell. Some of the fibers that extend from the cen...
    • Nuclear Envelope Breakdown, organism-specific biosystem (from REACTOME)
      Nuclear Envelope Breakdown, organism-specific biosystemThe nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    gamete generation IEA
    Inferred from Electronic Annotation
    more info
     
    mesoderm development IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear envelope disassembly TAS
    Traceable Author Statement
    more info
     
    nuclear envelope organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of triglyceride biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein dephosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    Nem1-Spo7 phosphatase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    CTD nuclear envelope phosphatase 1
    Names
    C-terminal domain nuclear envelope phosphatase 1
    dullard homolog
    serine/threonine-protein phosphatase dullard
    NP_001137247.1
    NP_056158.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001143775.1NP_001137247.1  CTD nuclear envelope phosphatase 1

      See identical proteins and their annotated locations for NP_001137247.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC003688, AC120057, BC009295
      Consensus CDS
      CCDS11093.1
      UniProtKB/Swiss-Prot
      O95476
      Related
      ENSP00000460683, OTTHUMP00000128375, ENST00000574322, OTTHUMT00000220030
      Conserved Domains (1) summary
      TIGR02251
      Location:61229
      HIF-SF_euk; Dullard-like phosphatase domain
    2. NM_015343.4NP_056158.2  CTD nuclear envelope phosphatase 1

      See identical proteins and their annotated locations for NP_056158.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AC003688, AC120057, BC009295
      Consensus CDS
      CCDS11093.1
      UniProtKB/Swiss-Prot
      O95476
      Related
      ENSP00000321732, OTTHUMP00000258327, ENST00000318988, OTTHUMT00000440216
      Conserved Domains (1) summary
      TIGR02251
      Location:61229
      HIF-SF_euk; Dullard-like phosphatase domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p7 Primary Assembly

      Range
      7243587..7251940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      7155699..7164051 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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