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    FOSL1 FOS like 1, AP-1 transcription factor subunit [ Homo sapiens (human) ]

    Gene ID: 8061, updated on 23-May-2018
    Official Symbol
    FOSL1provided by HGNC
    Official Full Name
    FOS like 1, AP-1 transcription factor subunitprovided by HGNC
    Primary source
    HGNC:HGNC:13718
    See related
    Ensembl:ENSG00000175592 MIM:136515; Vega:OTTHUMG00000166715
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRA; FRA1; fra-1
    Summary
    The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in gall bladder (RPKM 16.7), urinary bladder (RPKM 10.2) and 13 other tissues See more
    Orthologs
    See FOSL1 in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (65892136..65900526, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (65659616..65667997, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene cathepsin W Neighboring gene FGF1 intracellular binding protein Neighboring gene coiled-coil domain containing 85B Neighboring gene NFE2L2 motif-containing MPRA enhancer 146/147 Neighboring gene chromosome 11 open reading frame 68

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    NHGRI GWA Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to extracellular stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    placenta blood vessel development IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA-templated transcription, initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    pri-miRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    response to cAMP IEA
    Inferred from Electronic Annotation
    more info
     
    response to corticosterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    response to gravity IEA
    Inferred from Electronic Annotation
    more info
     
    response to hydrogen peroxide IEA
    Inferred from Electronic Annotation
    more info
     
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    response to progesterone IEA
    Inferred from Electronic Annotation
    more info
     
    response to virus TAS
    Traceable Author Statement
    more info
    PubMed 
    transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    PubMed 
    vitellogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    fos-related antigen 1
    Names
    FOS like 1, AP-1 trancription factor subunit
    FOS-like antigen-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300844.1NP_001287773.1  fos-related antigen 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, AK299050, BM764259, BQ937004
      Consensus CDS
      CCDS73324.1
      UniProtKB/Swiss-Prot
      P15407
      UniProtKB/TrEMBL
      E9PPX2
      Related
      ENSP00000436276.1, OTTHUMP00000234039, ENST00000531493.5, OTTHUMT00000391169
      Conserved Domains (2) summary
      PRK13729
      Location:98214
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cl21462
      Location:99132
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    2. NM_001300855.1NP_001287784.1  fos-related antigen 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA120824, BC016648, BP222547, BQ937004
      Consensus CDS
      CCDS76437.1
      UniProtKB/Swiss-Prot
      P15407
      UniProtKB/TrEMBL
      E9PKL5
      Related
      ENSP00000431594.1, OTTHUMP00000234040, ENST00000532401.1, OTTHUMT00000391170
    3. NM_001300856.1NP_001287785.1  fos-related antigen 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, BC016648, BQ937004, CB123614
      UniProtKB/Swiss-Prot
      P15407
      Conserved Domains (1) summary
      cd14721
      Location:49102
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
    4. NM_001300857.1NP_001287786.1  fos-related antigen 1 isoform 5

      See identical proteins and their annotated locations for NP_001287786.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AA120824, BC016648, BM846271, BQ937004
      Consensus CDS
      CCDS76436.1
      UniProtKB/Swiss-Prot
      P15407
      Related
      ENSP00000393302.2, OTTHUMP00000234037, ENST00000448083.6, OTTHUMT00000391167
      Conserved Domains (2) summary
      PRK13729
      Location:35148
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cl21462
      Location:3466
      bZIP; Basic leucine zipper (bZIP) domain of bZIP transcription factors: a DNA-binding and dimerization domain
    5. NM_005438.4NP_005429.1  fos-related antigen 1 isoform 1

      See identical proteins and their annotated locations for NP_005429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA120824, BC016648, BQ937004
      Consensus CDS
      CCDS8121.1
      UniProtKB/Swiss-Prot
      P15407
      UniProtKB/TrEMBL
      A0A0S2Z595
      Related
      ENSP00000310170.2, OTTHUMP00000234038, ENST00000312562.6, OTTHUMT00000391168
      Conserved Domains (2) summary
      PRK13729
      Location:129250
      PRK13729; conjugal transfer pilus assembly protein TraB; Provisional
      cd14721
      Location:115168
      bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

    RNA

    1. NR_125339.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate splice junction at the 3' end of the first exon and lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
      Source sequence(s)
      AA120824, BC016648, BQ937004

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

      Range
      65892136..65900526 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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