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    DGKB diacylglycerol kinase beta [ Homo sapiens (human) ]

    Gene ID: 1607, updated on 6-Sep-2017
    Official Symbol
    DGKBprovided by HGNC
    Official Full Name
    diacylglycerol kinase betaprovided by HGNC
    Primary source
    HGNC:HGNC:2850
    See related
    Ensembl:ENSG00000136267 MIM:604070; Vega:OTTHUMG00000152477
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DGK; DAGK2; DGK-BETA
    Summary
    Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
    Orthologs
    Location:
    7p21.2
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (14145049..14974777, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (14184674..14943281, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375162 Neighboring gene solute carrier family 34 member 2 pseudogene Neighboring gene ribosomal protein L6 pseudogene 21 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 26 Neighboring gene uncharacterized LOC105375164 Neighboring gene uncharacterized LOC105375163 Neighboring gene general transcription factor IIIA pseudogene 5 Neighboring gene alkylglycerol monooxygenase

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
    NHGRI GWA Catalog
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    NHGRI GWA Catalog
    Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
    NHGRI GWA Catalog
    Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.
    NHGRI GWA Catalog
    Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.
    NHGRI GWA Catalog
    Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
    NHGRI GWA Catalog
    Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
    NHGRI GWA Catalog
    New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
    NHGRI GWA Catalog
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • KIAA0718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    diacylglycerol kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    diacylglycerol kinase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    glycerolipid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    lipid phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    platelet activation TAS
    Traceable Author Statement
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    diacylglycerol kinase beta
    Names
    90 kDa diacylglycerol kinase
    DAG kinase beta
    diacylglycerol kinase, beta 90kDa
    diglyceride kinase beta
    NP_001337634.1
    NP_663733.1
    XP_005249685.1
    XP_005249686.1
    XP_005249687.1
    XP_005249688.1
    XP_011513455.1
    XP_011513456.1
    XP_011513458.1
    XP_011513459.1
    XP_011513460.1
    XP_016867272.1
    XP_016867273.1
    XP_016867274.1
    XP_016867275.1
    XP_016867276.1
    XP_016867277.1
    XP_016867278.1
    XP_016867279.1
    XP_016867280.1
    XP_016867281.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029494.2 RefSeqGene

      Range
      76122..834729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350705.1NP_001337634.1  diacylglycerol kinase beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1).
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Consensus CDS
      CCDS47547.1
      Conserved Domains (6) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    2. NM_001350706.1NP_001337635.1  diacylglycerol kinase beta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    3. NM_001350707.1NP_001337636.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 5 and 6, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    4. NM_001350708.1NP_001337637.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    5. NM_001350709.1NP_001337638.1  diacylglycerol kinase beta isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 4 and 5, encodes isoform 3.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    6. NM_001350711.1NP_001337640.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 8 and 9, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    7. NM_001350712.1NP_001337641.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 7 and 9, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    8. NM_001350714.1NP_001337643.1  diacylglycerol kinase beta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 7 and 8, encodes isoform 4.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    9. NM_001350715.1NP_001337644.1  diacylglycerol kinase beta isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:575755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    10. NM_001350716.1NP_001337645.1  diacylglycerol kinase beta isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:575755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    11. NM_001350717.1NP_001337646.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    12. NM_001350718.1NP_001337647.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    13. NM_001350719.1NP_001337648.1  diacylglycerol kinase beta isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform 6.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    14. NM_001350720.1NP_001337649.1  diacylglycerol kinase beta isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 7.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:563743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    15. NM_001350721.1NP_001337650.1  diacylglycerol kinase beta isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 7.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:563743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    16. NM_001350722.1NP_001337651.1  diacylglycerol kinase beta isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 18, encodes isoform 8.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:540720
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:398519
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:203252
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:111180
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:268319
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:14107
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    17. NM_001350723.1NP_001337652.1  diacylglycerol kinase beta isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 17, encodes isoform 8.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:540720
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:398519
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:203252
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:111180
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:268319
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:14107
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    18. NM_001350724.1NP_001337653.1  diacylglycerol kinase beta isoform 9

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) encodes isoform 9.
      Source sequence(s)
      AC005039, AC005248, AC006045, AC006150, AC011229, AC073258, AC105459
      Conserved Domains (6) summary
      smart00045
      Location:532712
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:390511
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:196245
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:104173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:261312
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7100
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    19. NM_145695.2NP_663733.1  diacylglycerol kinase beta isoform 2

      See identical proteins and their annotated locations for NP_663733.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has a distinct 3' UTR and 3' coding region compared to variant (1). The encoded protein (2) has a shorter, alternate C-terminus compared to isoform (1).
      Source sequence(s)
      AC005039, BC105005, DA321150
      Consensus CDS
      CCDS47548.1
      UniProtKB/Swiss-Prot
      Q9Y6T7
      Related
      ENSP00000386066.3, OTTHUMP00000201740, ENST00000406247.7, OTTHUMT00000326357
      Conserved Domains (8) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:440772
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:154218
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6149
      DAG_kinase_N; Diacylglycerol kinase N-terminus

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      14145049..14974777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011789.1XP_016867278.1  diacylglycerol kinase beta isoform X5

      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    2. XM_017011784.1XP_016867273.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      B5MBY2
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    3. XM_011515154.2XP_011513456.1  diacylglycerol kinase beta isoform X1

      See identical proteins and their annotated locations for XP_011513456.1

      UniProtKB/Swiss-Prot
      Q9Y6T7
      Conserved Domains (6) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    4. XM_017011787.1XP_016867276.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      B5MCD5
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    5. XM_005249629.2XP_005249686.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      B5MBY2
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    6. XM_005249628.2XP_005249685.1  diacylglycerol kinase beta isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6T7
      Related
      ENSP00000385780.2, OTTHUMP00000201739, ENST00000403951.6, OTTHUMT00000326356
      Conserved Domains (6) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    7. XM_011515158.2XP_011513460.1  diacylglycerol kinase beta isoform X6

      Conserved Domains (6) summary
      smart00045
      Location:563743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    8. XM_011515157.2XP_011513459.1  diacylglycerol kinase beta isoform X5

      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    9. XM_011515156.2XP_011513458.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      B5MCD5
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    10. XM_005249630.2XP_005249687.1  diacylglycerol kinase beta isoform X3

      Conserved Domains (6) summary
      smart00045
      Location:575755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    11. XM_017011783.1XP_016867272.1  diacylglycerol kinase beta isoform X2

      UniProtKB/TrEMBL
      B5MBY2
      Related
      ENSP00000384909.1, OTTHUMP00000201745, ENST00000402815.5, OTTHUMT00000326368
      Conserved Domains (6) summary
      smart00045
      Location:581761
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:439560
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    12. XM_011515153.2XP_011513455.1  diacylglycerol kinase beta isoform X1

      UniProtKB/Swiss-Prot
      Q9Y6T7
      Conserved Domains (6) summary
      smart00045
      Location:582762
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    13. XM_017011788.1XP_016867277.1  diacylglycerol kinase beta isoform X5

      Conserved Domains (6) summary
      smart00045
      Location:570750
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:428549
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    14. XM_017011785.1XP_016867274.1  diacylglycerol kinase beta isoform X3

      Conserved Domains (6) summary
      smart00045
      Location:575755
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:433554
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    15. XM_017011786.1XP_016867275.1  diacylglycerol kinase beta isoform X4

      UniProtKB/TrEMBL
      B5MCD5
      Related
      ENSP00000385031.1, OTTHUMP00000201744, ENST00000407950.5, OTTHUMT00000326366
      Conserved Domains (6) summary
      smart00045
      Location:574754
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:432553
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    16. XM_005249631.3XP_005249688.1  diacylglycerol kinase beta isoform X6

      Conserved Domains (6) summary
      smart00045
      Location:563743
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:421542
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:238287
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:146215
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:303354
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam14513
      Location:7142
      DAG_kinase_N; Diacylglycerol kinase N-terminus
    17. XM_017011790.1XP_016867279.1  diacylglycerol kinase beta isoform X7

      Conserved Domains (7) summary
      smart00046
      Location:440561
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd00029
      Location:245294
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00051
      Location:153222
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam00130
      Location:310361
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam13499
      Location:154218
      EF-hand_7; EF-hand domain pair
      pfam14513
      Location:6149
      DAG_kinase_N; Diacylglycerol kinase N-terminus
      cl02440
      Location:582679
      DAGK_acc; Diacylglycerol kinase accessory domain
    18. XM_017011791.1XP_016867280.1  diacylglycerol kinase beta isoform X8

    19. XM_017011792.1XP_016867281.1  diacylglycerol kinase beta isoform X9

    RNA

    1. XR_001744571.1 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      14184411..14880671 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004080.2: Suppressed sequence

      Description
      NM_004080.2: This RefSeq was removed because currently there is insufficient support for the 5' end of the transcript.
    Support Center