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    Prpf19 pre-mRNA processing factor 19 [ Mus musculus (house mouse) ]

    Gene ID: 28000, updated on 23-May-2018
    Official Symbol
    Prpf19provided by MGI
    Official Full Name
    pre-mRNA processing factor 19provided by MGI
    Primary source
    MGI:MGI:106247
    See related
    Ensembl:ENSMUSG00000024735 Vega:OTTMUSG00000046847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PSO4; Snev; Prp19; NMP200; AA617263; AL024362; D19Wsu55e
    Expression
    Ubiquitous expression in ovary adult (RPKM 53.7), adrenal adult (RPKM 44.5) and 28 other tissues See more
    Orthologs
    See Prpf19 in Genome Data Viewer
    Location:
    19 A; 19 7.33 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (10895231..10909559)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (10969782..10980022)

    Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 15, member 3 Neighboring gene transmembrane protein 132A Neighboring gene transmembrane protein 109 Neighboring gene zona pellucida glycoprotein 1 Neighboring gene prostaglandin D2 receptor 2 Neighboring gene coiled-coil domain containing 86

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-ubiquitin ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    cellular protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
     
    generation of catalytic spliceosome for first transesterification step IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inner cell mass cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of astrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of astrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction involved in DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    spliceosomal tri-snRNP complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
     
    Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
     
    U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     
    NOT spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Preferred Names
    pre-mRNA-processing factor 19
    Names
    PRP19/PSO4 homolog
    PRP19/PSO4 pre-mRNA processing factor 19 homolog
    RING-type E3 ubiquitin transferase PRP19
    nuclear matrix protein 200
    nuclear matrix protein SNEV
    prp19 beta
    senescence evasion factor
    NP_001240772.1
    NP_001240773.1
    NP_598890.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253843.1NP_001240772.1  pre-mRNA-processing factor 19 isoform 1

      See identical proteins and their annotated locations for NP_001240772.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC132402, AK047693
      Consensus CDS
      CCDS57135.1
      UniProtKB/Swiss-Prot
      Q99KP6
      Related
      ENSMUSP00000136858.2, OTTMUSP00000066932, ENSMUST00000179297.2, OTTMUST00000121505
      Conserved Domains (4) summary
      cd00200
      Location:242522
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:243281
      7WD40; WD40 repeat [structural motif]
      pfam08606
      Location:69152
      Prp19; Prp19/Pso4-like
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
    2. NM_001253844.1NP_001240773.1  pre-mRNA-processing factor 19 isoform 3

      See identical proteins and their annotated locations for NP_001240773.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC132402, AK076998
      UniProtKB/Swiss-Prot
      Q99KP6
      Conserved Domains (3) summary
      cd00200
      Location:138418
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:139177
      7WD40; WD40 repeat [structural motif]
      pfam08606
      Location:148
      Prp19; Prp19/Pso4-like
    3. NM_134129.4NP_598890.1  pre-mRNA-processing factor 19 isoform 2

      See identical proteins and their annotated locations for NP_598890.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC132402, AK164681
      Consensus CDS
      CCDS79687.1
      UniProtKB/Swiss-Prot
      Q99KP6
      Related
      ENSMUSP00000025642.8, OTTMUSP00000066931, ENSMUST00000025642.13, OTTMUST00000121504
      Conserved Domains (4) summary
      cd00200
      Location:223503
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:224262
      7WD40; WD40 repeat [structural motif]
      pfam08606
      Location:69133
      Prp19; Prp19/Pso4-like
      cd16656
      Location:456
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

      Range
      10895231..10909559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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