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    CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

    Gene ID: 868, updated on 14-Jun-2018
    Official Symbol
    CBLBprovided by HGNC
    Official Full Name
    Cbl proto-oncogene Bprovided by HGNC
    Primary source
    HGNC:HGNC:1542
    See related
    Ensembl:ENSG00000114423 MIM:604491; Vega:OTTHUMG00000150654
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cbl-b; RNF56; Nbla00127
    Summary
    This gene encodes an E3 ubiquitin-protein ligase which promotes proteosome-mediated protein degradation by transferring ubiquitin from an E2 ubiquitin-conjugating enzyme to a substrate. The encoded protein is involved in the regulation of immune response by limiting T-cell receptor, B-cell receptor, and high affinity immunoglobulin epsilon receptor activation. Studies in mouse suggest that this gene is involved in antifungal host defense and that its inhibition leads to increased fungal killing. Manipulation of this gene may be beneficial in implementing immunotherapies for a variety of conditions, including cancer, autoimmune diseases, allergies, and infections. [provided by RefSeq, Sep 2017]
    Expression
    Ubiquitous expression in lymph node (RPKM 6.7), gall bladder (RPKM 4.7) and 25 other tissues See more
    Orthologs
    See CBLB in Genome Data Viewer
    Location:
    3q13.11
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (105655461..105869552, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374306..105589354, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC107986109 Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC105374026

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Jun 15 11:32:44 2016

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystem (from WikiPathways)
      Angiopoietin Like Protein 8 Regulatory Pathway, organism-specific biosystemThe hepatic ANGPTL8 (Angiopoietin Like Protein 8) regulatory pathway represents an up-to-date curated interactive pathway for all of the interactions from the known regulators of ANGPTL8 and updated ...
    • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystem (from REACTOME)
      Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myeloid leukemia (CML) is a clonal myeloproliferative disorder of a pluripotent stem cell. The natural history of CML has a triphasic clinical course comprising of an initial chronic phase (C...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystemInsulin signaling influences energy metabolism as well as growth. The presence of insulin signals the fed state, and this signal is passed via the AKT branch, which leads to the uptake of glucose fro...
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Proteoglycans in cancer, organism-specific biosystem (from KEGG)
      Proteoglycans in cancer, organism-specific biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Proteoglycans in cancer, conserved biosystem (from KEGG)
      Proteoglycans in cancer, conserved biosystemMany proteoglycans (PGs) in the tumor microenvironment have been shown to be key macromolecules that contribute to biology of various types of cancer including proliferation, adhesion, angiogenesis a...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T-Cell antigen Receptor (TCR) Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    NLS-bearing protein import into nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of epidermal growth factor-activated receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence b
    Cbl proto-oncogene B, E3 ubiquitin protein ligase
    Cbl proto-oncogene, E3 ubiquitin protein ligase B
    RING finger protein 56
    RING-type E3 ubiquitin transferase CBL-B
    SH3-binding protein CBL-B
    casitas B-lineage lymphoma proto-oncogene b
    signal transduction protein CBL-B
    NP_001308715.1
    NP_001308717.1
    NP_001308718.1
    NP_001308719.1
    NP_001308720.1
    NP_001308722.1
    NP_001308723.1
    NP_001308724.1
    NP_001308725.1
    NP_001308726.1
    NP_001308727.1
    NP_001308728.1
    NP_001308735.1
    NP_001308736.1
    NP_001308737.1
    NP_001308740.1
    NP_001308742.1
    NP_001308745.1
    NP_001308749.1
    NP_001308751.1
    NP_733762.2
    XP_011511559.1
    XP_011511561.2
    XP_016862884.1
    XP_016862885.1
    XP_016862886.1
    XP_016862887.1
    XP_016862888.1
    XP_016862889.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_055547.1 RefSeqGene

      Range
      5541..219092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1179

    mRNA and Protein(s)

    1. NM_001321786.1NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Consensus CDS
      CCDS87116.1
      Related
      ENSP00000377598.3, ENST00000394030.7
      Conserved Domains (5) summary
      cd09920
      Location:276372
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:401443
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:959999
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:72195
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:199282
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. NM_001321788.1NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: Variants 2 and 3 encode the same isoform (b).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Consensus CDS
      CCDS2948.1
      UniProtKB/Swiss-Prot
      Q13191
      Related
      ENSP00000496761.1, ENST00000646825.1
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. NM_001321789.1NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:276372
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:401443
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:910950
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:72195
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:199282
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    4. NM_001321790.1NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

      Status: REVIEWED

      Source sequence(s)
      AC016138, AI221219, AK302533, AK316276
      UniProtKB/TrEMBL
      B4DYP3, B7ZAG1
      Conserved Domains (5) summary
      cd09920
      Location:270366
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:395437
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:909949
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:66189
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:193276
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    5. NM_001321791.1NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6 and 7 encode the same isoform (e).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    6. NM_001321793.1NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

      Status: REVIEWED

      Description
      Transcript Variant: Variants 6 and 7 encode the same isoform (e).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    7. NM_001321794.1NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

      Status: REVIEWED

      Description
      Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    8. NM_001321795.1NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

      Status: REVIEWED

      Description
      Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    9. NM_001321796.1NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

      Status: REVIEWED

      Description
      Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485
      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    10. NM_001321797.1NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

      Status: REVIEWED

      Description
      Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    11. NM_001321798.1NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

      Status: REVIEWED

      Description
      Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    12. NM_001321799.1NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

      Status: REVIEWED

      Description
      Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
      Source sequence(s)
      AC016138, AC112485
      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:838878
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    13. NM_001321806.1NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

      Status: REVIEWED

      Description
      Transcript Variant: Variants 14 and 15 encode the same isoform (j).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:671711
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    14. NM_001321807.1NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

      Status: REVIEWED

      Description
      Transcript Variant: Variants 14 and 15 encode the same isoform (j).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:671711
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    15. NM_001321808.1NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:627667
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    16. NM_001321811.1NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

      Status: REVIEWED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (l).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:622662
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    17. NM_001321813.1NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

      Status: REVIEWED

      Description
      Transcript Variant: Variants 17 and 18 encode the same isoform (l).
      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:622662
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    18. NM_001321816.1NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (3) summary
      cd09920
      Location:184
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:113155
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:578618
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    19. NM_001321820.1NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (1) summary
      cd14392
      Location:491531
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    20. NM_001321822.1NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Conserved Domains (1) summary
      cd14392
      Location:488528
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    21. NM_170662.5NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

      See identical proteins and their annotated locations for NP_733762.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AC016138, AI221219, AK094184, BC032851, BC065915, U26710
      Consensus CDS
      CCDS2948.1
      UniProtKB/Swiss-Prot
      Q13191
      UniProtKB/TrEMBL
      B3KSS7
      Related
      ENSP00000264122.4, OTTHUMP00000198145, ENST00000264122.8
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RNA

    1. NR_135806.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
    2. NR_135807.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
    3. NR_135808.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
    4. NR_135809.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
    5. NR_135810.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
    6. NR_135811.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185
      Related
      ENST00000645759.1
    7. NR_135812.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC016138, AC112485, AC126185

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p12 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

      Range
      105655461..105869552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513257.1XP_011511559.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      See identical proteins and their annotated locations for XP_011511559.1

      UniProtKB/Swiss-Prot
      Q13191
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:373415
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44167
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_017007395.1XP_016862884.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      Related
      ENSP00000496352.1, ENST00000643322.1
    3. XM_017007398.1XP_016862887.1  E3 ubiquitin-protein ligase CBL-B isoform X5

    4. XM_017007399.1XP_016862888.1  E3 ubiquitin-protein ligase CBL-B isoform X6

      Conserved Domains (5) summary
      cd09920
      Location:199295
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd00162
      Location:324366
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd14392
      Location:882922
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44140
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:123205
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    5. XM_017007400.1XP_016862889.1  E3 ubiquitin-protein ligase CBL-B isoform X7

    6. XM_017007397.1XP_016862886.1  E3 ubiquitin-protein ligase CBL-B isoform X4

    7. XM_017007396.1XP_016862885.1  E3 ubiquitin-protein ligase CBL-B isoform X3

    8. XM_011513259.3XP_011511561.2  E3 ubiquitin-protein ligase CBL-B isoform X8

      Related
      ENSP00000384938.1, OTTHUMP00000198147, ENST00000405772.5

    RNA

    1. XR_001740339.1 RNA Sequence

    2. XR_001740338.1 RNA Sequence

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